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Haematopoiesis in the Era of Advanced Single-cell Technologies

Overview
Journal Nat Cell Biol
Specialty Cell Biology
Date 2019 Jan 4
PMID 30602765
Citations 57
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Abstract

The molecular and functional characterization of single cells at scale has emerged as a key driver to unravel tissue biology. Thus, it is important to understand the strengths and limitations of transcriptomic approaches, molecular barcoding and functional assays used to study cellular properties at the single-cell level. Here, we review recent relevant work from the haematopoietic system and discuss how to interpret and integrate data obtained with different technologies.

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References
1.
Muller-Sieburg C, Cho R, Thoman M, Adkins B, Sieburg H . Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. Blood. 2002; 100(4):1302-9. View