Circulating IRF8-expressing CD123CD127 Lymphoid Progenitors: Key Players in Human Hematopoiesis

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2023 Aug 17

PMID 37591714

Authors

Kai Ling Liang

Elisa Laurenti

Tom Taghon

Affiliations

Soon will be listed here.

Abstract

Lymphopoiesis is the process in which B and T cells, and innate lymphoid cells (ILCs) develop from hematopoietic progenitors that exhibit early lymphoid priming. The branching points where lymphoid-primed human progenitors are further specified to B/T/ILC differentiation trajectories remain unclear. Here, we discuss the emerging role of interferon regulatory factor (IRF)8 as a key factor to bridge human lymphoid and dendritic cell (DC) differentiation, and the current evidence for the existence of circulating and tissue-resident CD123CD127 lymphoid progenitors. We propose a model whereby DC/B/T/ILC lineage programs in circulating CD123CD127 lymphoid progenitors are expressed in balance. Upon tissue seeding, the tissue microenvironment tilts this molecular balance towards a specific lineage, thereby determining in vivo lineage fates. Finally, we discuss the translational implication of these lymphoid precursors.

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