Urinary β2-microglobulin and Disease Activity in Patients with Tubulointerstitial Nephritis and Uveitis Syndrome

Overview

Journal J Ophthalmic Inflamm Infect

Publisher Springer

Specialty Ophthalmology

Date 2018 Dec 31

PMID 30594950

Citations 7

Authors

Lorraine M Provencher

Aaron M Fairbanks

Michael D Abramoff

Nasreen A Syed

Affiliations

Soon will be listed here.

Abstract

Background: Urinary β2-microglobulin (Uβ2M) is elevated in tubulointerstitial nephritis and uveitis (TINU) syndrome and has emerged as an important diagnostic tool. This study aims to determine whether Uβ2M correlates with uveitis activity in TINU.

Methods: Retrospective observational case series of nine patients with TINU and ≥ 30 days follow-up. Presenting symptoms, visual acuity, uveitis characteristics, follow-up, Uβ2M, serum creatinine (SCr), urinalysis, and renal biopsy results were collected.

Results: A correlation between Uβ2M and anterior chamber (AC) cell (r = 0.69, 95% CI 0.46-0.84), flare (r = 0.65, 95% CI 0.39-0.81), trended toward a stronger correlation than SCr and AC cell (r = 0.59, 95% CI 0.29-0.79), flare (r = 0.52, 95% CI 0.19-0.75). Uβ2M decreased over 1-2 years while SCr returned to normal within a few months.

Conclusions: Uβ2M correlate with uveitis activity and trend down over the course of TINU. Uβ2M may serve as a useful tool in determining where patients are in their systemic disease course.

Citing Articles

A Comprehensive Review of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome.

Bograd A, Heiligenhaus A, Reuter S, Tappeiner C Biomedicines. 2025; 13(2).

PMID: 40002713 PMC: 11853424. DOI: 10.3390/biomedicines13020300.

Clinical outcomes in paediatric tubulointerstitial nephritis and uveitis syndrome (TINU).

Mandel M, Elhusseiny A, Davidson S, Rockter A, Levin A, Huang L Eye (Lond). 2024; 38(17):3318-3324.

PMID: 39085599 PMC: 11584886. DOI: 10.1038/s41433-024-03286-9.

Diagnostic and Management Strategies of Tubulointerstitial Nephritis and Uveitis Syndrome (TINU): Current Perspectives.

Sanchez-Quiros J, Giralt L, Fonollosa A, Robles I, Carreno E Clin Ophthalmol. 2023; 17:2625-2630.

PMID: 37701464 PMC: 10494573. DOI: 10.2147/OPTH.S404644.

Diagnosis and Characteristics of Presentation of Tubulointerstitial Nephritis and Uveitis Syndrome During the COVID-2019 Pandemic.

Huang L, Ta Kim D, Rosenberg C, Lin P, Suhler E Ocul Immunol Inflamm. 2023; 32(7):1351-1358.

PMID: 37699166 PMC: 10927609. DOI: 10.1080/09273948.2023.2244077.

Ocular manifestations and clinical outcomes in Tubulointerstitial Nephritis and Uveitis Syndrome (TINU).

Uludag Kirimli G, Hassan M, Onghanseng N, Or C, Yasar C, Park S Eye (Lond). 2023; 38(2):349-356.

PMID: 37626158 PMC: 10810898. DOI: 10.1038/s41433-023-02695-6.

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