Diagnosis and Characteristics of Presentation of Tubulointerstitial Nephritis and Uveitis Syndrome During the COVID-2019 Pandemic

Overview

Journal Ocul Immunol Inflamm

Publisher Informa Healthcare

Specialty Ophthalmology

Date 2023 Sep 12

PMID 37699166

Authors

Lingling Huang

David Ta Kim

Christopher R Rosenberg

Phoebe Lin

Eric Suhler

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare the diagnosis and clinical features of tubulointerstitial nephritis and uveitis syndrome (TINU) before and during the COVID-19 pandemic.

Methods: Retrospective chart review.

Results: Before the COVID-19 pandemic (March 2017 to March 2019), 1/561 (0.18%) new patient was diagnosed with TINU. During the pandemic (March 2020 to March 2022), 15/581 (2.58%) new patients were diagnosed with TINU. We found a significant increase in TINU cases during the pandemic (P=0.0005). Various posterior segment findings were observed in 2/3 (66.7%) patients before the pandemic and 13/15 (86.7%) patients during the pandemic, including disc edema, chorioretinal scars, disc leakage, and peripheral vascular leakage.

Conclusion: This is the first study reporting an increased number of TINU during the COVID-19 pandemic. With most of the American population now exposed to COVID-19, a large multi-center epidemiological study would be helpful to investigate any association of COVID-19 disease or vaccination with TINU in recent years.

Citing Articles

Tubulointerstitial Nephritis and Uveitis Syndrome During the COVID-19 Pandemic: A Case Series.

Ozdemir Yalcinsoy K, Gungor A, Karakaya D, Ozdal L, Kilic M, Ozdamar Erol Y Turk J Ophthalmol. 2024; 54(1):5-10.

PMID: 38385308 PMC: 10895161. DOI: 10.4274/tjo.galenos.2023.24280.

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