Inhibition of Stearoyl CoA Desaturase-1 Activity Suppresses Tumour Progression and Improves Prognosis in Human Bladder Cancer

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2018 Dec 29

PMID 30592142

Citations 37

Authors

Chiyuan Piao

Xiaolu Cui

Bo Zhan

Jun Li

Zeliang Li

Zhenhua Li

Xiankui Liu

Jianbin Bi

Zhe Zhang

Chuize Kong

Affiliations

Soon will be listed here.

Abstract

Urinary bladder neoplasm is one of the most common cancers worldwide. Cancer stem cells (CSCs) have been proven to be an important cause of cancer progression and poor prognosis. In the present study, we established bladder CSCs and identified the crucial differentially expressed genes (DEGs) between these cells and parental bladder cancer cells. Analyses of bioinformatics data and clinical samples from local hospitals showed that stearoyl CoA desaturase-1 (SCD) was the key factor among the DEGs. A significant correlation between SCD gene expression and poor prognosis among patients with bladder cancer was observed in our data. Loss-of-function experiments further revealed that the SCD inhibitor A939572 and SCD gene interference reduced cell proliferation and invasion. The above data suggest that SCD may serve as a novel marker for the prediction of tumour progression and poor prognosis in patients with bladder cancer.

Citing Articles

Prognostic feature based on androgen-responsive genes in bladder cancer and screening for potential targeted drugs.

Zhao J, Zhang Q, Zhu C, Yuqi W, Zhang G, Wang Q BioData Min. 2024; 17(1):59.

PMID: 39695796 PMC: 11657289. DOI: 10.1186/s13040-024-00377-x.

Stearoyl CoA desaturase inhibition can effectively induce apoptosis in bladder cancer stem cells.

Li Y, Piao C, Kong C Cancer Cell Int. 2024; 24(1):357.

PMID: 39472909 PMC: 11520891. DOI: 10.1186/s12935-024-03540-w.

An automated network-based tool to search for metabolic vulnerabilities in cancer.

Valcarcel L, Jose-Eneriz E, Ordonez R, Apaolaza I, Olaverri-Mendizabal D, Barrena N Nat Commun. 2024; 15(1):8685.

PMID: 39394196 PMC: 11470099. DOI: 10.1038/s41467-024-52725-4.

Advancing bladder cancer management: development of a prognostic model and personalized therapy.

Huang X, Du G, Yang Y, Su P, Chen S, Cai C Front Immunol. 2024; 15:1430792.

PMID: 39104534 PMC: 11298345. DOI: 10.3389/fimmu.2024.1430792.

Development of a propionate metabolism-related gene-based molecular subtypes and scoring system for predicting prognosis in bladder cancer.

Zheng F, Wang Z, Li S, Xiong S, Yuan Y, Zeng J Eur J Med Res. 2024; 29(1):393.

PMID: 39075554 PMC: 11285334. DOI: 10.1186/s40001-024-01982-6.

References

Millan-Rodriguez F, Salvador-Bayarri J, Palou J, Vicente-Rodriguez J . Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J Urol. 1999; 163(1):73-8. DOI: 10.1016/s0022-5347(05)67975-x. View

Zhang Y, Wang H, Zhang J, Lv J, Huang Y . Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Sci. 2013; 104(4):416-22. PMC: 7657137. DOI: 10.1111/cas.12108. View

MEDES G, Thomas A, WEINHOUSE S . Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 1953; 13(1):27-9. View

Zhu Z, Agren J, Mannisto S, Pietinen P, Eskelinen M, Syrjanen K . Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease. Nutr Cancer. 1995; 24(2):151-60. DOI: 10.1080/01635589509514403. View

Zureik M, Ducimetiere P, Warnet J, Orssaud G . Fatty acid proportions in cholesterol esters and risk of premature death from cancer in middle aged French men. BMJ. 1995; 311(7015):1251-4. PMC: 2551179. DOI: 10.1136/bmj.311.7015.1251. View

Fialkow P, Jacobson R, Papayannopoulou T . Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med. 1977; 63(1):125-30. DOI: 10.1016/0002-9343(77)90124-3. View

Chen W, Zheng R, Baade P, Zhang S, Zeng H, Bray F . Cancer statistics in China, 2015. CA Cancer J Clin. 2016; 66(2):115-32. DOI: 10.3322/caac.21338. View

Chan K, Espinosa I, Chao M, Wong D, Ailles L, Diehn M . Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A. 2009; 106(33):14016-21. PMC: 2720852. DOI: 10.1073/pnas.0906549106. View

Pisanu M, Noto A, De Vitis C, Morrone S, Scognamiglio G, Botti G . Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells. Cancer Lett. 2017; 406:93-104. DOI: 10.1016/j.canlet.2017.07.027. View

10.

Roongta U, Pabalan J, Wang X, Ryseck R, Fargnoli J, Henley B . Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res. 2011; 9(11):1551-61. DOI: 10.1158/1541-7786.MCR-11-0126. View

11.

Nashed M, Chisholm J, Igal R . Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells. Exp Biol Med (Maywood). 2012; 237(9):1007-17. DOI: 10.1258/ebm.2012.012126. View

12.

Chajes V, Joulin V, Clavel-Chapelon F . The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk. Curr Opin Lipidol. 2010; 22(1):6-10. DOI: 10.1097/MOL.0b013e3283404552. View

13.

Kim S, Choi H, Park S, Chang C, Kim E . Stearoyl CoA desaturase (SCD) facilitates proliferation of prostate cancer cells through enhancement of androgen receptor transactivation. Mol Cells. 2011; 31(4):371-7. PMC: 3933960. DOI: 10.1007/s10059-011-0043-5. View

14.

Malumbres M, Barbacid M . Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009; 9(3):153-66. DOI: 10.1038/nrc2602. View

15.

Miller K, Siegel R, Lin C, Mariotto A, Kramer J, Rowland J . Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016; 66(4):271-89. DOI: 10.3322/caac.21349. View

16.

Zoeller R, Wood R . The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. Biochim Biophys Acta. 1985; 845(3):380-8. DOI: 10.1016/0167-4889(85)90202-2. View

17.

Hess D, Chisholm J, Igal R . Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010; 5(6):e11394. PMC: 2894866. DOI: 10.1371/journal.pone.0011394. View

18.

Kurzrock E, Lieu D, Degraffenried L, Chan C, Isseroff R . Label-retaining cells of the bladder: candidate urothelial stem cells. Am J Physiol Renal Physiol. 2008; 294(6):F1415-21. DOI: 10.1152/ajprenal.00533.2007. View

19.

Scaglia N, Igal R . Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol. 2008; 33(4):839-50. View

20.

Vivanco I, Sawyers C . The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002; 2(7):489-501. DOI: 10.1038/nrc839. View