XEN Implant and Trabeculectomy Medium-term Quality of Life Assessment and Comparison of Results

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2018 Dec 28

PMID 30588427

Citations 10

Authors

Ana Luisa Basilio

Nuno Moura-Coelho

Ines Passos

Mariana Sa Cardoso

Isabel Domingues

Maria Reina

Rita Flores

Teresa Gomes

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate and compare the quality of life of patients submitted to XEN implant or trabeculectomy and the relationship with potentially involved variables.

Methods: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN (group 1) and trabeculectomy (group 2) between October 2015 and February 2017. The studied variables were: age, gender, follow-up time, need of topical anti-hypertensive therapy, visual acuity and intraocular pressure (IOP). The quantification of the quality of life was attained through the Glaucoma Symptom Scale (GSS) questionnaire.

Results: Totally 34 eyes (34 patients) were included, 17 in each group. The mean GSS scores for group 1 were 42.6±6.8 (median, 47; p25, 36.5; p75, 48.5) and for group 2 it was 41.6±7.0 (median, 43; p25, 36.5; p75, 47.0; =0.34). There was a strong negative correlation between the need for topical anti-hypertensive drugs and the GSS result in both groups (=-0.88, <0.01, =-0.59, =0.01, respectively) and a moderate negative correlation with IOP in group 1 (=-0.50, =0.03).

Conclusion: The analysis demonstrates the non-inferiority of medium-term quality of life of one group in relation to the other (XEN implant and trabeculectomy). The number of topical anti-hypertensive drugs and IOP negatively influenced the quality of life.

Citing Articles

XEN45 Implant in Medically Controlled vs. Uncontrolled Eyes-Differential IOP Changes in Real-Life Conditions.

Julio G, Larena R, Marmol M, Soldevila A, Canut M, Pavan J J Clin Med. 2024; 13(12).

PMID: 38929940 PMC: 11204868. DOI: 10.3390/jcm13123406.

Minimally Invasive Bleb Surgery for Glaucoma: A Health Technology Assessment.

Ont Health Technol Assess Ser. 2024; 24(1):1-151.

PMID: 38332948 PMC: 10849035.

Managing the ocular surface after glaucoma filtration surgery: an orphan topic.

Agnifili L, Figus M, Sacchi M, Oddone F, Villani E, Ferrari G Graefes Arch Clin Exp Ophthalmol. 2023; 262(7):2039-2056.

PMID: 38091058 DOI: 10.1007/s00417-023-06333-5.

XEN-45 implantation for refractory uveitic glaucoma.

Evers C, Anton A, Bohringer D, Kallee S, Keye P, Ness T Graefes Arch Clin Exp Ophthalmol. 2023; 262(3):937-948.

PMID: 37855957 PMC: 10907455. DOI: 10.1007/s00417-023-06254-3.

[Why trabeculectomy is better than its reputation].

Strzalkowska A, Dietlein T, Erb C, Hoffmann E Ophthalmologie. 2022; 119(10):1000-1005.

PMID: 36074170 DOI: 10.1007/s00347-022-01720-5.

References

Janz N, Wren P, Lichter P, Musch D, Gillespie B, Guire K . Quality of life in newly diagnosed glaucoma patients : The Collaborative Initial Glaucoma Treatment Study. Ophthalmology. 2001; 108(5):887-97; discussion 898. DOI: 10.1016/s0161-6420(00)00624-2. View

Mangione C, Lee P, Gutierrez P, Spritzer K, Berry S, Hays R . Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol. 2001; 119(7):1050-8. DOI: 10.1001/archopht.119.7.1050. View

Simao L, Lana-Peixoto M, Araujo C, Moreira M, Teixeira A . The Brazilian version of the 25-Item National Eye Institute Visual Function Questionnaire: translation, reliability and validity. Arq Bras Oftalmol. 2008; 71(4):540-6. DOI: 10.1590/s0004-27492008000400014. View

Fernandez S, Pardinas N, Laliena J, Pablo L, Diaz S, Perez S . [Long-term tensional results after trabeculectomy. A comparative study among types of glaucoma and previous medical treatment]. Arch Soc Esp Oftalmol. 2009; 84(7):345-51. DOI: 10.4321/s0365-66912009000700005. View

Guedes R, Guedes V, Freitas S, Chaoubah A . Quality of life of medically versus surgically treated glaucoma patients. J Glaucoma. 2012; 22(5):369-73. DOI: 10.1097/IJG.0b013e31824ceb8b. View

Burr J, Azuara-Blanco A, Avenell A, Tuulonen A . Medical versus surgical interventions for open angle glaucoma. Cochrane Database Syst Rev. 2012; 9):CD004399. PMC: 11707325. DOI: 10.1002/14651858.CD004399.pub3. View

Black N . Patient reported outcome measures could help transform healthcare. BMJ. 2013; 346:f167. DOI: 10.1136/bmj.f167. View

Costa V, Marcon I, Galvao Filho R, Malta R . The prevalence of ocular surface complaints in Brazilian patients with glaucoma or ocular hypertension. Arq Bras Oftalmol. 2013; 76(4):221-5. DOI: 10.1590/s0004-27492013000400006. View

Brandao L, Grieshaber M . Update on Minimally Invasive Glaucoma Surgery (MIGS) and New Implants. J Ophthalmol. 2013; 2013:705915. PMC: 3863473. DOI: 10.1155/2013/705915. View

10.

Lewis R . Ab interno approach to the subconjunctival space using a collagen glaucoma stent. J Cataract Refract Surg. 2014; 40(8):1301-6. DOI: 10.1016/j.jcrs.2014.01.032. View

11.

SooHoo J, Seibold L, Radcliffe N, Kahook M . Minimally invasive glaucoma surgery: current implants and future innovations. Can J Ophthalmol. 2014; 49(6):528-33. DOI: 10.1016/j.jcjo.2014.09.002. View

12.

Hirneiss C, Kortum K . [Quality of Life in Patients with Glaucoma]. Klin Monbl Augenheilkd. 2016; 233(2):148-53. DOI: 10.1055/s-0041-110397. View

13.

Quaranta L, Riva I, Gerardi C, Oddone F, Floriani I, Konstas A . Quality of Life in Glaucoma: A Review of the Literature. Adv Ther. 2016; 33(6):959-81. PMC: 4920851. DOI: 10.1007/s12325-016-0333-6. View

14.

Pahlitzsch M, Klamann M, Pahlitzsch M, Gonnermann J, Torun N, Bertelmann E . Is there a change in the quality of life comparing the micro-invasive glaucoma surgery (MIGS) and the filtration technique trabeculectomy in glaucoma patients?. Graefes Arch Clin Exp Ophthalmol. 2016; 255(2):351-357. DOI: 10.1007/s00417-016-3550-4. View

15.

Kerr N, Wang J, Barton K . Minimally invasive glaucoma surgery as primary stand-alone surgery for glaucoma. Clin Exp Ophthalmol. 2016; 45(4):393-400. DOI: 10.1111/ceo.12888. View

16.

Kotecha A, Feuer W, Barton K, Gedde S . Quality of Life in the Tube Versus Trabeculectomy Study. Am J Ophthalmol. 2017; 176:228-235. DOI: 10.1016/j.ajo.2017.01.019. View

17.

Hirooka K, Nitta E, Ukegawa K, Tsujikawa A . Vision-related quality of life following glaucoma filtration surgery. BMC Ophthalmol. 2017; 17(1):66. PMC: 5429566. DOI: 10.1186/s12886-017-0466-7. View

18.

Ansari E . An Update on Implants for Minimally Invasive Glaucoma Surgery (MIGS). Ophthalmol Ther. 2017; 6(2):233-241. PMC: 5693836. DOI: 10.1007/s40123-017-0098-2. View

19.

Grover D, Flynn W, Bashford K, Lewis R, Duh Y, Nangia R . Performance and Safety of a New Ab Interno Gelatin Stent in Refractory Glaucoma at 12 Months. Am J Ophthalmol. 2017; 183:25-36. DOI: 10.1016/j.ajo.2017.07.023. View

20.

Lavia C, Dallorto L, Maule M, Ceccarelli M, Fea A . Minimally-invasive glaucoma surgeries (MIGS) for open angle glaucoma: A systematic review and meta-analysis. PLoS One. 2017; 12(8):e0183142. PMC: 5574616. DOI: 10.1371/journal.pone.0183142. View