A Model of Neuropathic Pain in Brachial Plexus Avulsion Injury and Associated Spinal Glial Cell Activation

Overview

Journal J Pain Res

Publisher Dove Medical Press

Date 2018 Dec 28

PMID 30588069

Citations 10

Authors

Ao-Lin Hou

Wen-Dong Xu

Affiliations

Soon will be listed here.

Abstract

Background: Neuropathic pain is a common and intractable sequel of brachial plexus injury.

Materials And Methods: To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury.

Results: Behavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. GFAP expression in the cervical spinal cord appeared on day 1 post-injury and increased on day 4. Ionized calcium-binding adaptor molecule 1 expression appeared on day 1 post-injury and increased until day 28. Therefore, the brachial plexus avulsion injury model can imitate the development of neuropathic pain and maintain it.

Conclusion: The activation of astrocyte and microglia in the spinal cord plays a key role in the mechanism and treatment of neuropathic pain.

Citing Articles

Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization.

Xian H, Guo H, Liu Y, Ma S, Zhao R, Zhang J Cell Biosci. 2025; 15(1):12.

PMID: 39891150 PMC: 11786554. DOI: 10.1186/s13578-025-01354-5.

Methylcobalamin in Combination with Early Intervention of Low-Intensity Pulsed Ultrasound Potentiates Nerve Regeneration and Functional Recovery in a Rat Brachial Plexus Injury Model.

Hsieh Y, Lu Y, Yang N, Yang C Int J Mol Sci. 2023; 24(18).

PMID: 37762159 PMC: 10530533. DOI: 10.3390/ijms241813856.

Acetylglutamine facilitates motor recovery and alleviates neuropathic pain after brachial plexus root avulsion in rats.

Wu L, Chen S, He B, Zhou G, Xu Y, Zhu G J Transl Med. 2023; 21(1):563.

PMID: 37612586 PMC: 10464467. DOI: 10.1186/s12967-023-04399-7.

Quercetin Ameliorates Neuropathic Pain after Brachial Plexus Avulsion Suppressing Oxidative Damage through Inhibition of PKC/MAPK/ NOX Pathway.

Huang Y, Zhang X, Zou Y, Yuan Q, Xian Y, Lin Z Curr Neuropharmacol. 2023; 21(11):2343-2361.

PMID: 37533160 PMC: 10556381. DOI: 10.2174/1570159X21666230802144940.

miR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis.

Jin X, Zheng W, Chi S, Cui T, He W Dev Neurosci. 2022; 45(1):37-52.

PMID: 36470227 PMC: 10129035. DOI: 10.1159/000528450.

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