High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome

Overview

Journal J Med Biochem

Specialty Biochemistry

Date 2018 Dec 26

PMID 30584411

Citations 3

Authors

Barbara Kraszewska-Glomba

Marta Myszka

Magdalena Krajewska

Leszek Szenborn

Affiliations

Soon will be listed here.

Abstract

PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). We found a high prevalence (43.3%) of anti-mCRP antibodies in PFAPA patients during their febrile episodes, which implies the possible involvement of anti-mCRP antibodies in PFAPA pathogenesis.

Citing Articles

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Diagnostic performance of routine blood parameters in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome.

Onur H, Rahmanali Onur A J Clin Lab Anal. 2023; 37(11-12):e24934.

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PFAPA Syndrome: Clinical, Laboratory and Therapeutic Features in a Single-Centre Cohort.

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