Olive Oil Effects on Colorectal Cancer

Overview

Journal Nutrients

Date 2018 Dec 26

PMID 30583613

Citations 42

Authors

Antonio Maria Borzi

Antonio Biondi

Francesco Basile

Salvatore Luca

Enzo Saretto Dante Vicari

Marco Vacante

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer is the fourth cause of cancer-related death worldwide. A Mediterranean diet showed protective action against colorectal cancer due to the intake of different substances. Olive oil is a fundamental component of the Mediterranean diet. Olive oil is rich in high-value health compounds (such as monounsaturated free fatty acids, squalene, phytosterols, and phenols). Phenolic compounds exert favourable effects on free radicals, inflammation, gut microbiota, and carcinogenesis. The interaction between gut microbiota and olive oil consumption could modulate colonic microbial composition or activity, with a possible role in cancer prevention. Gut microbiota is able to degrade some substances found in olive oil, producing active metabolites with chemopreventive action. Further clinical research is needed to clarify the beneficial effects of olive oil and its components. A better knowledge of the compounds found in olive oil could lead to the development of nutritional supplements or chemotherapeutic agents with a potential in the prevention and treatment of colorectal cancer.

Citing Articles

The Olive Oil Phenolic -(-)-Oleocanthal Suppresses Colorectal Cancer Progression and Recurrence by Modulating SMYD2-EZH2 and c-MET Activation.

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PMID: 39940255 PMC: 11821053. DOI: 10.3390/nu17030397.

Anti-colorectal cancer activity of constructed oleogels based on encapsulated bioactive canola extract in lecithin for edible semisolid applications.

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Squalene in Nanoparticles Improves Antiproliferative Effect on Human Colon Carcinoma Cells Through Apoptosis by Disturbances in Redox Balance.

Bidooki S, Quero J, Sanchez-Marco J, Herrero-Continente T, Marmol I, Lasheras R Int J Mol Sci. 2024; 25(23).

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Protective Effect of Extra Virgin Olive Oil on Cancers, Gastrointestinal Cancers, and All-Cause Mortality: A Competing Risk Analysis in a Southern Italian Cohort.

Bonfiglio C, Reddavide R, Cisternino A, Campanella A, Fontana L, Giannelli G Cancers (Basel). 2024; 16(21).

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Oleuropein impact on colorectal cancer.

Nsairat H, Jaber A, Faddah H, Ahmad S Future Sci OA. 2024; 10(1):FSO.

PMID: 38817366 PMC: 11137855. DOI: 10.2144/fsoa-2023-0131.

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