Olive Oil, Diet and Colorectal Cancer: an Ecological Study and a Hypothesis

Overview

Journal J Epidemiol Community Health

Specialty Health Services

Date 2000 Sep 16

PMID 10990479

Citations 19

Authors

M Stoneham

M Goldacre

V Seagroatt

L Gill

Affiliations

Soon will be listed here.

Abstract

Study Objectives: Colorectal cancer (CRC) is a common cancer in many western countries and is probably caused in part by dietary factors. Southern European countries have lower incidence rates of CRC than many other western countries. It was postulated that, because olive oil is thought to influence bile salt secretion patterns in rats, it may influence the occurrence of CRC. The purpose of this study was to compare national levels of dietary factors, with particular reference to olive oil, with national differences in CRC incidence.

Design: Ecological study using existing international databases. Incidence rates for CRC, food supply data, and olive oil consumption data were extracted from published sources, combined, and analysed to calculate the correlations between CRC and 10 dietary factors. Associations were then explored using stepwise multiple regression.

Setting: 28 countries from four continents.

Main Results: 76% of the intercountry variation in CRC incidence rates was explained by three significant dietary factors-meat, fish and olive oil-in combination. Meat and fish were positively associated, and olive oil was negatively associated, with CRC incidence.

Conclusion: Olive oil may have a protective effect on the development of CRC. The proposed hypothesis is that olive oil may influence secondary bile acid patterns in the colon that, in turn, might influence polyamine metabolism in colonic enterocytes in ways that reduce progression from normal mucosa to adenoma and carcinoma.

Citing Articles

Biological Activities of Molecules Derived from L. Tested .

Marrone G, Urciuoli S, Candi E, Bernini R, Vanni G, Masci C Life (Basel). 2024; 14(1).

PMID: 38255664 PMC: 10820526. DOI: 10.3390/life14010049.

Oleuropein exhibits anticarcinogen effects against gastric cancer cell lines.

Turkdogan M, Kocyigit A, Guler E, Ozer O, Demir K, Ugur H Mol Biol Rep. 2023; 50(11):9099-9105.

PMID: 37747682 DOI: 10.1007/s11033-023-08773-y.

Is Extra Virgin Olive Oil the Critical Ingredient Driving the Health Benefits of a Mediterranean Diet? A Narrative Review.

Flynn M, Tierney A, Itsiopoulos C Nutrients. 2023; 15(13).

PMID: 37447242 PMC: 10346407. DOI: 10.3390/nu15132916.

Comparison of Fatty Acid Contents and MMP-1 Inhibitory Effects of the Two Antarctic Fish, and .

Lee S, Koo M, Han D, Kim I, Lee J, Kim J Molecules. 2022; 27(14).

PMID: 35889426 PMC: 9317339. DOI: 10.3390/molecules27144554.

Looking for Minor Phenolic Compounds in Extra Virgin Olive Oils Using Neutron and Raman Spectroscopies.

Senesi R, Andreani C, Baglioni P, de Carvalho L, Licoccia S, Marques M Antioxidants (Basel). 2021; 10(5).

PMID: 33922163 PMC: 8145310. DOI: 10.3390/antiox10050643.

References

Hill M, Drasar B, Hawksworth G, Aries V, CROWTHER J, Williams R . Bacteria and aetiology of cancer of large bowel. Lancet. 1971; 1(7690):95-100. DOI: 10.1016/s0140-6736(71)90837-3. View

Hill M . Meat and colorectal cancer: what does the evidence show?. Eur J Cancer Prev. 1998; 6(5):415-7. DOI: 10.1097/00008469-199710000-00001. View

Armstrong B, DOLL R . Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975; 15(4):617-31. DOI: 10.1002/ijc.2910150411. View

Hepner G . Altered bile acid metabolism in vegetarians. Am J Dig Dis. 1975; 20(10):935-46. DOI: 10.1007/BF01070879. View

McMichael A, McCall M, Hartshorne J, Woodings T . Patterns of gastro-intestinal cancer in European migrants to Australia: the role of dietary change. Int J Cancer. 1980; 25(4):431-7. DOI: 10.1002/ijc.2910250402. View

Botham K, BOYD G . The effect of dietary fat on bile salt synthesis in rat liver. Biochim Biophys Acta. 1983; 752(2):307-14. DOI: 10.1016/0005-2760(83)90128-5. View

Terpstra O, van Blankenstein M, Dees J, Eilers G . Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology. 1987; 92(3):704-8. DOI: 10.1016/0016-5085(87)90021-7. View

Sattler J, Hesterberg R, Schmidt U, Crombach M, Lorenz W . Inhibition of intestinal diamine oxidase by detergents: a problem for drug formulations with water insoluble agents applied by the intravenous route?. Agents Actions. 1987; 20(3-4):270-3. DOI: 10.1007/BF02074688. View

Moorehead R, Campbell G, Donaldson J, McKelvey S . Relationship between duodenal bile acids and colorectal neoplasia. Gut. 1987; 28(11):1454-9. PMC: 1433701. DOI: 10.1136/gut.28.11.1454. View

10.

Stadler J, Yeung K, Furrer R, Marcon N, Himal H, Bruce W . Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer. Cancer Lett. 1988; 38(3):315-20. DOI: 10.1016/0304-3835(88)90023-7. View

11.

Cummings J, Bingham S . Dietary fibre, fermentation and large bowel cancer. Cancer Surv. 1987; 6(4):601-21. View

12.

Kusche J, Menningen R, Leisten L, Krakamp B . Large bowel tumor promotion by diamine oxidase inhibition: animal model and clinical aspects. Adv Exp Med Biol. 1988; 250:745-52. DOI: 10.1007/978-1-4684-5637-0_66. View

13.

Benito E, Obrador A, Stiggelbout A, Bosch F, Mulet M, Munoz N . A population-based case-control study of colorectal cancer in Majorca. I. Dietary factors. Int J Cancer. 1990; 45(1):69-76. DOI: 10.1002/ijc.2910450114. View

14.

Bingham S . Mechanisms and experimental and epidemiological evidence relating dietary fibre (non-starch polysaccharides) and starch to protection against large bowel cancer. Proc Nutr Soc. 1990; 49(2):153-71. DOI: 10.1079/pns19900021. View

15.

Dowling R . Polyamines in intestinal adaptation and disease. Digestion. 1990; 46 Suppl 2:331-44. DOI: 10.1159/000200406. View

16.

van Faassen A, Hazen M, van den Brandt P, van den Bogaard A, Hermus R, JANKNEGT R . Bile acids and pH values in total feces and in fecal water from habitually omnivorous and vegetarian subjects. Am J Clin Nutr. 1993; 58(6):917-22. DOI: 10.1093/ajcn/58.6.917. View

17.

Serra-Majem L, La Vecchia C, Ribas-Barba L, Lucchini F, Ramon J, Salleras L . Changes in diet and mortality from selected cancers in southern Mediterranean countries, 1960-1989. Eur J Clin Nutr. 1993; 47 Suppl 1:S25-34. View

18.

Nagengast F, Grubben M, van Munster I . Role of bile acids in colorectal carcinogenesis. Eur J Cancer. 1995; 31A(7-8):1067-70. DOI: 10.1016/0959-8049(95)00216-6. View

19.

Bautista D, Obrador A, Moreno V, Cabeza E, Canet R, Benito E . Ki-ras mutation modifies the protective effect of dietary monounsaturated fat and calcium on sporadic colorectal cancer. Cancer Epidemiol Biomarkers Prev. 1997; 6(1):57-61. View

20.

Owen R . Faecal steroids and colorectal carcinogenesis. Scand J Gastroenterol Suppl. 1997; 222:76-82. DOI: 10.1080/00365521.1997.11720725. View