The Role of Subchondral Bone, and Its Histomorphology, on the Dynamic Viscoelasticity of Cartilage, Bone and Osteochondral Cores

Overview

Journal Osteoarthritis Cartilage

Specialties Orthopedics
Rheumatology

Date 2018 Dec 22

PMID 30576795

Citations 22

Authors

N L A Fell

B M Lawless

S C Cox

M E Cooke

N M Eisenstein

D E T Shepherd

D M Espino

Affiliations

Soon will be listed here.

Abstract

Objective: Viscoelastic properties of articular cartilage have been characterised at physiological frequencies. However, studies investigating the interaction between cartilage and subchondral bone and the influence of underlying bone histomorphometry on the viscoelasticity of cartilage are lacking.

Method: Dynamic Mechanical Analysis (DMA) has been used to quantify the dynamic viscoelasticity of bovine tibial plateau osteochondral cores, over a frequency sweep from 1 to 88 Hz. Specimens (approximately aged between 18 and 30 months) were neither osteoarthritic nor otherwise compromised. A maximum nominal stress of 1.7 MPa was induced. Viscoelastic properties of cores have been compared with that of its components (cartilage and bone) in terms of the elastic and viscous components of both structural stiffness and material modulus. Micro-computed tomography scans were used to quantify the histomorphological properties of the subchondral bone.

Results: Opposing frequency-dependent loss stiffness, and modulus, trends were witnessed for osteochondral tissues: for cartilage it increased logarithmically (P < 0.05); for bone it decreased logarithmically (P < 0.05). The storage stiffness of osteochondral cores was logarithmically frequency-dependent (P < 0.05), however, the loss stiffness was typically frequency-independent (P > 0.05). A linear relationship between the subchondral bone plate (SBP) thickness and cartilage thickness (P < 0.001) was identified. Cartilage loss modulus was linearly correlated to bone mineral density (BMD) (P < 0.05) and bone volume (P < 0.05).

Conclusion: The relationship between the subchondral bone histomorphometry and cartilage viscoelasticity (namely loss modulus) and thickness, have implications for the initiation and progression of osteoarthritis (OA) through an altered ability of cartilage to dissipate energy.

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References

Wachter N, Augat P, Krischak G, Sarkar M, Mentzel M, Kinzl L . Prediction of strength of cortical bone in vitro by microcomputed tomography. Clin Biomech (Bristol). 2001; 16(3):252-6. DOI: 10.1016/s0268-0033(00)00092-9. View

Mahjoub M, Berenbaum F, Houard X . Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis. Osteoporos Int. 2012; 23 Suppl 8:S841-6. DOI: 10.1007/s00198-012-2161-0. View

Barker M, Seedhom B . The relationship of the compressive modulus of articular cartilage with its deformation response to cyclic loading: does cartilage optimize its modulus so as to minimize the strains arising in it due to the prevalent loading regime?. Rheumatology (Oxford). 2001; 40(3):274-84. DOI: 10.1093/rheumatology/40.3.274. View

M Espino D, E T Shepherd D, Hukins D . Viscoelastic properties of bovine knee joint articular cartilage: dependency on thickness and loading frequency. BMC Musculoskelet Disord. 2014; 15:205. PMC: 4068975. DOI: 10.1186/1471-2474-15-205. View

Aspden R . Fibre reinforcing by collagen in cartilage and soft connective tissues. Proc Biol Sci. 1994; 258(1352):195-200. DOI: 10.1098/rspb.1994.0162. View

Fulcher G, Hukins D, E T Shepherd D . Viscoelastic properties of bovine articular cartilage attached to subchondral bone at high frequencies. BMC Musculoskelet Disord. 2009; 10:61. PMC: 2698871. DOI: 10.1186/1471-2474-10-61. View

Yamashita J, Li X, Furman B, Rawls H, Wang X, Agrawal C . Collagen and bone viscoelasticity: a dynamic mechanical analysis. J Biomed Mater Res. 2002; 63(1):31-6. DOI: 10.1002/jbm.10086. View

Aula A, Toyras J, Tiitu V, Jurvelin J . Simultaneous ultrasound measurement of articular cartilage and subchondral bone. Osteoarthritis Cartilage. 2010; 18(12):1570-6. DOI: 10.1016/j.joca.2010.09.009. View

Perilli E, Briggs A, Kantor S, Codrington J, Wark J, Parkinson I . Failure strength of human vertebrae: prediction using bone mineral density measured by DXA and bone volume by micro-CT. Bone. 2012; 50(6):1416-25. DOI: 10.1016/j.bone.2012.03.002. View

10.

Shepherd D, Seedhom B . A technique for measuring the compressive modulus of articular cartilage under physiological loading rates with preliminary results. Proc Inst Mech Eng H. 1997; 211(2):155-65. DOI: 10.1243/0954411971534278. View

11.

Burr D, Radin E . Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?. Rheum Dis Clin North Am. 2003; 29(4):675-85. DOI: 10.1016/s0889-857x(03)00061-9. View

12.

Wu Z, Ovaert T, Niebur G . Viscoelastic properties of human cortical bone tissue depend on gender and elastic modulus. J Orthop Res. 2011; 30(5):693-9. PMC: 3288480. DOI: 10.1002/jor.22001. View

13.

Verteramo A, Seedhom B . Effect of a single impact loading on the structure and mechanical properties of articular cartilage. J Biomech. 2007; 40(16):3580-9. DOI: 10.1016/j.jbiomech.2007.06.002. View

14.

Radin E, Yang K, Riegger C, Kish V, OConnor J . Relationship between lower limb dynamics and knee joint pain. J Orthop Res. 1991; 9(3):398-405. DOI: 10.1002/jor.1100090312. View

15.

Temple D, Cederlund A, Lawless B, Aspden R, M Espino D . Viscoelastic properties of human and bovine articular cartilage: a comparison of frequency-dependent trends. BMC Musculoskelet Disord. 2016; 17(1):419. PMC: 5054593. DOI: 10.1186/s12891-016-1279-1. View

16.

Szarko M, Muldrew K, Bertram J . Freeze-thaw treatment effects on the dynamic mechanical properties of articular cartilage. BMC Musculoskelet Disord. 2010; 11:231. PMC: 2958988. DOI: 10.1186/1471-2474-11-231. View

17.

Lawless B, Barnes S, M Espino D, E T Shepherd D . Viscoelastic properties of a spinal posterior dynamic stabilisation device. J Mech Behav Biomed Mater. 2016; 59:519-526. DOI: 10.1016/j.jmbbm.2016.03.011. View

18.

Radin E, PARKER H, Pugh J, Steinberg R, Paul I, Rose R . Response of joints to impact loading. 3. Relationship between trabecular microfractures and cartilage degeneration. J Biomech. 1973; 6(1):51-7. DOI: 10.1016/0021-9290(73)90037-7. View

19.

Simon S, Paul I, Mansour J, Munro M, Abernethy P, Radin E . Peak dynamic force in human gait. J Biomech. 1981; 14(12):817-22. DOI: 10.1016/0021-9290(81)90009-9. View

20.

Lawless B, Sadeghi H, Temple D, Dhaliwal H, M Espino D, Hukins D . Viscoelasticity of articular cartilage: Analysing the effect of induced stress and the restraint of bone in a dynamic environment. J Mech Behav Biomed Mater. 2017; 75:293-301. PMC: 5636614. DOI: 10.1016/j.jmbbm.2017.07.040. View