Detection of Neuraminidase Inhibitor-resistant Influenza A (H1N1)pdm09 Viruses Obtained from Influenza Surveillance in Indonesia

Overview

Journal SAGE Open Med

Publisher Sage Publications

Specialty General Medicine

Date 2018 Dec 22

PMID 30574303

Citations 2

Authors

Hana Apsari Pawestri

Arie Ardiansyah Nugraha

Nur Ika Hariastuti

Vivi Setiawaty

Affiliations

Soon will be listed here.

Abstract

Background: Influenza antiviral resistance has been shown to occur in many countries and is commonly found in influenza A(H1N1)pdm09 and A(H3N2). In this study, we monitored and investigated the neuraminidase inhibitor resistance of influenza A(H1N1)pdm09 viruses through the influenza surveillance system in Indonesia.

Methods: A total of 4752 clinical specimens were collected from patients with influenza-like illness and severe acute respiratory infection during the year 2016. An allelic discrimination assay was conducted by a single base substitution or a single-nucleotide polymorphism that is specific to the H275 wild-type and Y275 mutant. Sequencing was performed to confirm the H275Y mutations, and we analysed the phylogenetic relationship.

Results: The first occurrence of oseltamivir-resistant influenza A(H1N1)pdm09 was observed in the samples from the influenza-like illness surveillance. Two H275Y oseltamivir-resistant viruses (0.74%) out of 272 influenza A(H1N1)pdm09 positives were found. Both of them were collected from untreated patients.

Conclusion: The number of oseltamivir-resistant influenza A(H1N1)pdm09 viruses in Indonesia is very low. However, it is necessary to continue with active surveillance for oseltamivir resistance in severe and mild cases.

Citing Articles

Molecular Characterization of Influenza A/H3N2 Virus Isolated from Indonesian Hajj and Umrah Pilgrims 2013 to 2014.

Agustiningsih A, Indalao I, Pangesti K, Sukowati C, Ramadhany R Life (Basel). 2023; 13(5).

PMID: 37240745 PMC: 10221221. DOI: 10.3390/life13051100.

Polygalasaponin F treats mice with pneumonia induced by influenza virus.

Ye Y, Wang H, Liu J, Zhao F, Xu P Inflammopharmacology. 2019; 28(1):299-310.

PMID: 31446589 PMC: 7102181. DOI: 10.1007/s10787-019-00633-1.

References

Beckett C, Kosasih H, Maroef C, Listiyaningsih E, Elyazar I, Wuryadi S . Influenza surveillance in Indonesia: 1999-2003. Clin Infect Dis. 2004; 39(4):443-9. DOI: 10.1086/422314. View

Bao Y, Bolotov P, Dernovoy D, Kiryutin B, Zaslavsky L, Tatusova T . The influenza virus resource at the National Center for Biotechnology Information. J Virol. 2007; 82(2):596-601. PMC: 2224563. DOI: 10.1128/JVI.02005-07. View

Hurt A, Ernest J, Deng Y, Iannello P, Besselaar T, Birch C . Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa. Antiviral Res. 2009; 83(1):90-3. DOI: 10.1016/j.antiviral.2009.03.003. View

Hurt A, Hardie K, Wilson N, Deng Y, Osbourn M, Gehrig N . Community transmission of oseltamivir-resistant A(H1N1)pdm09 influenza. N Engl J Med. 2011; 365(26):2541-2. DOI: 10.1056/NEJMc1111078. View

Hurt A, Hardie K, Wilson N, Deng Y, Osbourn M, Leang S . Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia. J Infect Dis. 2012; 206(2):148-57. PMC: 3379839. DOI: 10.1093/infdis/jis337. View

Kosasih H, Roselinda , Nurhayati , Klimov A, Xiyan X, Lindstrom S . Surveillance of influenza in Indonesia, 2003–2007. Influenza Other Respir Viruses. 2012; 7(3):312-20. PMC: 5779827. DOI: 10.1111/j.1750-2659.2012.00403.x. View

Poovorawan Y, Pyungporn S, Prachayangprecha S, Makkoch J . Global alert to avian influenza virus infection: from H5N1 to H7N9. Pathog Glob Health. 2013; 107(5):217-23. PMC: 4001451. DOI: 10.1179/2047773213Y.0000000103. View

Abed Y, Pizzorno A, Bouhy X, Rheaume C, Boivin G . Impact of potential permissive neuraminidase mutations on viral fitness of the H275Y oseltamivir-resistant influenza A(H1N1)pdm09 virus in vitro, in mice and in ferrets. J Virol. 2013; 88(3):1652-8. PMC: 3911590. DOI: 10.1128/JVI.02681-13. View

Kamali A, Holodniy M . Influenza treatment and prophylaxis with neuraminidase inhibitors: a review. Infect Drug Resist. 2013; 6:187-98. PMC: 3838482. DOI: 10.2147/IDR.S36601. View

10.

Takashita E, Ejima M, Itoh R, Miura M, Ohnishi A, Nishimura H . A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013. Euro Surveill. 2014; 19(1). DOI: 10.2807/1560-7917.es2014.19.1.20666. View

11.

Butler J, Hooper K, Petrie S, Lee R, Maurer-Stroh S, Reh L . Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A(H1N1)pdm09 influenza viruses. PLoS Pathog. 2014; 10(4):e1004065. PMC: 3974874. DOI: 10.1371/journal.ppat.1004065. View

12.

Kosasih H, Bratasena A, Pangesti K, Laras K, Samaan G . Managing seasonal influenza: oseltamivir treatment policy in indonesia?. Acta Med Indones. 2014; 46(1):58-65. View

13.

Grund S, Gkioule C, Termos T, Pfeifer N, Kobbe G, Verheyen J . Primarily oseltamivir-resistant influenza A (H1N1pdm09) virus evolving into a multidrug-resistant virus carrying H275Y and I223R neuraminidase substitutions. Antivir Ther. 2014; 20(1):97-100. DOI: 10.3851/IMP2811. View

14.

Meijer A, Rebelo-de-Andrade H, Correia V, Besselaar T, Drager-Dayal R, Fry A . Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013. Antiviral Res. 2014; 110:31-41. PMC: 8851378. DOI: 10.1016/j.antiviral.2014.07.001. View

15.

Takashita E, Meijer A, Lackenby A, Gubareva L, Rebelo-de-Andrade H, Besselaar T . Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014. Antiviral Res. 2015; 117:27-38. PMC: 9036627. DOI: 10.1016/j.antiviral.2015.02.003. View

16.

Souza T, Fintelman-Rodrigues N, Resende P, Mesquita M, Gregianini T, Bozza F . Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance. Mem Inst Oswaldo Cruz. 2015; 110(1):101-5. PMC: 4371223. DOI: 10.1590/0074-02760140330. View

17.

Li T, Chan M, Lee N . Clinical Implications of Antiviral Resistance in Influenza. Viruses. 2015; 7(9):4929-44. PMC: 4584294. DOI: 10.3390/v7092850. View

18.

Abraham M, Perkins J, Vilke G, Coyne C . Influenza in the Emergency Department: Vaccination, Diagnosis, and Treatment: Clinical Practice Paper Approved by American Academy of Emergency Medicine Clinical Guidelines Committee. J Emerg Med. 2016; 50(3):536-42. DOI: 10.1016/j.jemermed.2015.10.013. View

19.

Kumar S, Stecher G, Tamura K . MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol Biol Evol. 2016; 33(7):1870-4. PMC: 8210823. DOI: 10.1093/molbev/msw054. View

20.

Shu Y, McCauley J . GISAID: Global initiative on sharing all influenza data - from vision to reality. Euro Surveill. 2017; 22(13). PMC: 5388101. DOI: 10.2807/1560-7917.ES.2017.22.13.30494. View