The Regulatory Network of Nasopharyngeal Carcinoma Metastasis with a Focus on EBV, LncRNAs and MiRNAs

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2018 Dec 18

PMID 30555738

Citations 23

Authors

Chen-Xuan Zhao

Wei Zhu

Zheng-Qing Ba

Hong-Juan Xu

Wei-Dong Liu

Bin Zhu

Lei Wang

Yu-Jia Song

Shuai Yuan

Cai-Ping Ren

Affiliations

Soon will be listed here.

Abstract

Metastasis of nasopharyngeal carcinoma (NPC) remains a main cause of death for NPC patients even though great advances have been made in therapeutic approaches. An in-depth study into the molecular mechanisms of NPC metastasis will help us combat NPC. Epstein-Barr virus (EBV) infection is an evident feature of nonkeratinizing NPC and is strongly associated with tumor metastasis. Recently, long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) have become a hot topic of research due to their epigenetic regulatory roles in NPC metastasis. The EBV products, lncRNAs and miRNAs can target each other and share several common signaling pathways, which form an interconnected, complex molecular regulatory network. In this review, we discuss the features of this regulatory network and summarize the molecular mechanisms of NPC metastasis, focusing on EBV, lncRNAs and miRNAs with updated knowledge.

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