Mesoporous Silica-based Nanoplatforms for the Delivery of Photodynamic Therapy Agents

Overview

Journal J Pharm Investig

Publisher Springer

Specialty Chemistry

Date 2018 Dec 15

PMID 30546918

Citations 16

Authors

Suk Ho Hong

Yongdoo Choi

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy (PDT) is an established method for the treatment of cancer which utilizes light, a photosensitizer (PS), and oxygen. Unfavourable characteristics of most PSs, such as low solubility and tumour specificity have led many researchers to adopt nanoscale drug delivery platforms for use in PDT. Mesoporous silica nanoparticles (MSNs) form a significant part of that effort, due to their ease and controllability of synthesis, ease of loading, availability of diverse surface functionalization, and biocompatibility. Therefore, in this review, we discuss the properties of MSNs as they pertain to their use in PDT and review the latest advances in the field, comparing the different approaches currently being used.

Citing Articles

Synergistic effect of mesoporous silica nanocarrier-assisted photodynamic therapy and anticancer agent activity on lung cancer cells.

Guleryuz B, Isik A, Gulsoy M Lasers Med Sci. 2024; 39(1):91.

PMID: 38491201 PMC: 10942901. DOI: 10.1007/s10103-023-03969-x.

The Potential of Nano-Based Photodynamic Treatment as a Therapy against Oral Leukoplakia: A Narrative Review.

Angjelova A, Jovanova E, Polizzi A, Santonocito S, Giudice A, Isola G J Clin Med. 2023; 12(21).

PMID: 37959284 PMC: 10649116. DOI: 10.3390/jcm12216819.

Mesoporous Silica-Based Nanoplatforms Are Theranostic Agents for the Treatment of Inflammatory Disorders.

Sivamaruthi B, Thangaleela S, Kesika P, Suganthy N, Chaiyasut C Pharmaceutics. 2023; 15(2).

PMID: 36839761 PMC: 9960588. DOI: 10.3390/pharmaceutics15020439.

Liposomes loaded with dual clinical photosensitizers for enhanced photodynamic therapy of cervical cancer.

Alimu G, Yan T, Zhu L, Du Z, Ma R, Fan H RSC Adv. 2023; 13(6):3459-3467.

PMID: 36756546 PMC: 9872094. DOI: 10.1039/d2ra03055a.

Triphenylphosphonium Modified Mesoporous Silica Nanoparticle for Enhanced Algicidal Efficacy of Cyclohexyl-(3,4-dichlorobenzyl) Amine.

Kim H, Kim S, Park D, Cho H, Asadujjaman M, Jee J Int J Mol Sci. 2022; 23(19).

PMID: 36233203 PMC: 9569965. DOI: 10.3390/ijms231911901.

References

Zhang R, Wu C, Tong L, Tang B, Xu Q . Multifunctional core-shell nanoparticles as highly efficient imaging and photosensitizing agents. Langmuir. 2009; 25(17):10153-8. DOI: 10.1021/la902235d. View

Planas O, Bresoli-Obach R, Nos J, Gallavardin T, Ruiz-Gonzalez R, Agut M . Synthesis, photophysical characterization, and photoinduced antibacterial activity of methylene blue-loaded amino- and mannose-targeted mesoporous silica nanoparticles. Molecules. 2015; 20(4):6284-98. PMC: 6272360. DOI: 10.3390/molecules20046284. View

Huang X, Li L, Liu T, Hao N, Liu H, Chen D . The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano. 2011; 5(7):5390-9. DOI: 10.1021/nn200365a. View

Guo R, Peng H, Tian Y, Shen S, Yang W . Mitochondria-Targeting Magnetic Composite Nanoparticles for Enhanced Phototherapy of Cancer. Small. 2016; 12(33):4541-52. DOI: 10.1002/smll.201601094. View

Qian H, Guo H, Ho P, Mahendran R, Zhang Y . Mesoporous-silica-coated up-conversion fluorescent nanoparticles for photodynamic therapy. Small. 2009; 5(20):2285-90. DOI: 10.1002/smll.200900692. View

Luo D, Carter K, Miranda D, Lovell J . Chemophototherapy: An Emerging Treatment Option for Solid Tumors. Adv Sci (Weinh). 2017; 4(1):1600106. PMC: 5238751. DOI: 10.1002/advs.201600106. View

Yang Y, Yu M, Song H, Wang Y, Yu C . Preparation of fluorescent mesoporous hollow silica-fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy. Nanoscale. 2015; 7(28):11894-8. DOI: 10.1039/c5nr02769a. View

Wang Y, Yang G, Wang Y, Zhao Y, Jiang H, Han Y . Multiple imaging and excellent anticancer efficiency of an upconverting nanocarrier mediated by single near infrared light. Nanoscale. 2017; 9(14):4759-4769. DOI: 10.1039/c6nr09030c. View

Veronese F, Pasut G . PEGylation, successful approach to drug delivery. Drug Discov Today. 2005; 10(21):1451-8. DOI: 10.1016/S1359-6446(05)03575-0. View

10.

Lucky S, Soo K, Zhang Y . Nanoparticles in photodynamic therapy. Chem Rev. 2015; 115(4):1990-2042. DOI: 10.1021/cr5004198. View

11.

Teng I, Chang Y, Wang L, Lu H, Wu L, Yang C . Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer. Biomaterials. 2013; 34(30):7462-70. DOI: 10.1016/j.biomaterials.2013.06.001. View

12.

Kwon S, Singh R, Perez R, Abou Neel E, Kim H, Chrzanowski W . Silica-based mesoporous nanoparticles for controlled drug delivery. J Tissue Eng. 2013; 4:2041731413503357. PMC: 3764983. DOI: 10.1177/2041731413503357. View

13.

Hashizume H, Baluk P, Morikawa S, McLean J, Thurston G, Roberge S . Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol. 2000; 156(4):1363-80. PMC: 1876882. DOI: 10.1016/S0002-9440(10)65006-7. View

14.

Zhao Z, Huang Y, Shi S, Tang S, Li D, Chen X . Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy. Nanotechnology. 2014; 25(28):285701. DOI: 10.1088/0957-4484/25/28/285701. View

15.

Liu J, Bu W, Shi J . Silica coated upconversion nanoparticles: a versatile platform for the development of efficient theranostics. Acc Chem Res. 2015; 48(7):1797-805. DOI: 10.1021/acs.accounts.5b00078. View

16.

Dolmans D, Fukumura D, Jain R . Photodynamic therapy for cancer. Nat Rev Cancer. 2003; 3(5):380-7. DOI: 10.1038/nrc1071. View

17.

Tarn D, Ashley C, Xue M, Carnes E, Zink J, Brinker C . Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. Acc Chem Res. 2013; 46(3):792-801. PMC: 3686852. DOI: 10.1021/ar3000986. View

18.

Meng H, Yang S, Li Z, Xia T, Chen J, Ji Z . Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. ACS Nano. 2011; 5(6):4434-47. PMC: 3125420. DOI: 10.1021/nn103344k. View

19.

Konan Y, Gurny R, Allemann E . State of the art in the delivery of photosensitizers for photodynamic therapy. J Photochem Photobiol B. 2002; 66(2):89-106. DOI: 10.1016/s1011-1344(01)00267-6. View

20.

Li L, Liu T, Fu C, Tan L, Meng X, Liu H . Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape. Nanomedicine. 2015; 11(8):1915-24. DOI: 10.1016/j.nano.2015.07.004. View