Translocations Involving ETS Family Proteins in Human Cancer

Overview

Journal Integr Cancer Sci Ther

Publisher Open Access Text

Date 2018 Dec 14

PMID 30542624

Citations 5

Authors

Elizabeth A Fry

Ali Mallakin

Kazushi Inoue

Affiliations

Soon will be listed here.

Abstract

The ETS transcription factors regulate expression of genes involved in normal cell development, proliferation, differentiation, angiogenesis, and apoptosis, consisting of 28 family members in humans. Dysregulation of these transcription factors facilitates cell proliferation in cancers, and several members participate in invasion and metastasis by activating certain gene transcriptions. ETS1 and ETS2 are the founding members of the ETS family and regulate transcription by binding to ETS sequences. Three chimeric genes involving S genes have been identified in human cancers, which are in Ewing's sarcoma, in prostate cancer, and in acute lymphocytic leukemia. Although these fusion transcripts definitely contribute to the pathogenesis of the disease, the impact of these fusion transcripts on patients' prognosis is highly controversial. In the present review, the roles of ETS protein translocations in human carcinogenesis are discussed.

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