Diabetes and Arrhythmias: Pathophysiology, Mechanisms and Therapeutic Outcomes

Overview

Journal Front Physiol

Date 2018 Dec 12

PMID 30534081

Citations 64

Authors

Laurel A Grisanti

Affiliations

Soon will be listed here.

Abstract

The prevalence of diabetes is rapidly increasing and closely associated with cardiovascular morbidity and mortality. While the major cardiovascular complication associated with diabetes is coronary artery disease, it is becoming increasingly apparent that diabetes impacts the electrical conduction system in the heart, resulting in atrial fibrillation, and ventricular arrhythmias. The relationship between diabetes and arrhythmias is complex and multifactorial including autonomic dysfunction, atrial and ventricular remodeling and molecular alterations. This review will provide a comprehensive overview of the link between diabetes and arrhythmias with insight into the common molecular mechanisms, structural alterations and therapeutic outcomes.

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