Impact of Left Atrial Box Surface Ratio on the Recurrence After Ablation for Persistent Atrial Fibrillation

Overview

Journal Pacing Clin Electrophysiol

Date 2018 Dec 7

PMID 30520059

Citations 5

Authors

Fehmi Kece

Arthur J Scholte

Marta de Riva

Yoshihisa Naruse

Masaya Watanabe

Reza Alizadeh Dehnavi

Martin J Schalij

Katja Zeppenfeld

Serge A Trines

Affiliations

Soon will be listed here.

Abstract

Background: The posterior wall of the left atrium (LA) is a well-known substrate for atrial fibrillation (AF) maintenance. Isolation of the posterior wall between the pulmonary veins (box lesion) may improve ablation success. Box lesion surface area size varies depending on the individual anatomy. This retrospective study evaluates the influence of box lesion surface area as a ratio of total LA surface area (box surface ratio) on arrhythmia recurrence.

Methods: Seventy consecutive patients with persistent AF (63 ± 11 years, 53 men) undergoing computed tomography (CT) imaging and ablation procedure consisting of a first box lesion were included in this study. Box lesion surface area was measured on electroanatomical maps and total LA surface area was derived from CT. Patients were followed with 24-h electrocardiography and exercise tests at 3, 6, and 12 months after AF ablation. Arrhythmia recurrence was defined as any AF/atrial tachycardia (AT) beyond 3 months without antiarrhythmic drugs.

Results: During a median follow-up of 13 (interquartile range = 10-17) months, 42 (60%) patients had AF/AT recurrence. Multivariate Cox proportional regression analysis showed that a larger box surface ratio protected against recurrence (hazard ratio [HR] = 0.81; 95% confidence interval [CI] = 0.690-0.955; P = 0.012). Left atrial volume index (HR = 1.01 [0.990-1.024, P = 0.427] and a history of mitral valve surgery (HR = 2.90; 95% CI = 0.970-8.693; P = 0.057) were not associated with AF recurrence in multivariate analysis.

Conclusion: A larger box lesion surface area as a ratio of total LA surface area is protective for AF/AT recurrence after ablation for persistent AF.

Citing Articles

Value of Imaging in the Non-Invasive Prediction of Recurrence after Catheter Ablation in Patients with Atrial Fibrillation: An Up-to-Date Review.

Jing M, Li D, Xi H, Zhang Y, Zhou J Rev Cardiovasc Med. 2024; 24(8):241.

PMID: 39076720 PMC: 11266785. DOI: 10.31083/j.rcm2408241.

Ongoing substrate-driven atrial fibrillation "boxed" in the left atrial posterior wall with ablation: a case report.

Traykov V, Marchov D, Martinov E, El Abbady A, Gelev V, Dichtl W Front Cardiovasc Med. 2023; 10:1251874.

PMID: 37790595 PMC: 10542893. DOI: 10.3389/fcvm.2023.1251874.

Is Incomplete Left Atrial Posterior Wall Isolation Associated With Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation?.

Fujito T, Mochizuki A, Kamiyama N, Koyama M, Nagahara D, Miura T Circ Rep. 2021; 2(11):648-656.

PMID: 33693191 PMC: 7937498. DOI: 10.1253/circrep.CR-20-0044.

Left atrial effective conducting size predicts atrial fibrillation vulnerability in persistent but not paroxysmal atrial fibrillation.

Williams S, ONeill L, Roney C, Julia J, Metzner A, Reissmann B J Cardiovasc Electrophysiol. 2019; 30(9):1416-1427.

PMID: 31111557 PMC: 6746623. DOI: 10.1111/jce.13990.

Impact of left atrial box surface ratio on the recurrence after ablation for persistent atrial fibrillation.

Kece F, Scholte A, de Riva M, Naruse Y, Watanabe M, Alizadeh Dehnavi R Pacing Clin Electrophysiol. 2018; 42(2):208-215.

PMID: 30520059 PMC: 6850488. DOI: 10.1111/pace.13570.

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