Reprogramming Tumor Associated Macrophage Phenotype by a Polysaccharide from for Sarcoma Immunotherapy

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Dec 6

PMID 30513582

Citations 11

Authors

Qiu Li

Zhihui Hao

Yeting Hong

Wei He

Wenwen Zhao

Affiliations

Soon will be listed here.

Abstract

We report here the discovery of an acidic polysaccharide, namely IAPS-2, from the root of , with anti-tumor activity via a repolarizing tumor associated macrophages (TAMs) phenotype. We obtained IAPS-2 polysaccharide from this herb based on acidity and found that IAPS-2 expressed the activity of promoting the secretion of anti-tumor cytokines in macrophages. Furthermore, we evaluated its anti-tumor effect on TAM cells, through the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription (STAT) signaling. In particular, in the tumor murine model, IAPS-2 demonstrated that it could significantly inhibit the growth of tumors via modulating the function of TAMs and increase the animal survival rate. In summary, IAPS-2, with a clearly illustrated chemical composition, potent anti-tumor activity, and a solid mechanism of action, may be developed into a valuable therapeutic tool for cancer immunotherapy.

Citing Articles

Macrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming.

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Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment.

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NF-κB: Governing Macrophages in Cancer.

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