Importance of Th22 Cell Disequilibrium in Immune Thrombocytopenic Purpura

Overview

Journal Med Sci Monit

Specialties General Medicine
Pathology

Date 2018 Dec 5

PMID 30510151

Citations 3

Authors

Feng-Xia Zhan

Juan Li

Min Fang

Juan Ding

Qian Wang

Affiliations

Soon will be listed here.

Abstract

BACKGROUND The disequilibrium of T helper (Th) cells play an important role in the occurrence and development of immune thrombocytopenic purpura (ITP). Th22 cells, as a newly discovered subset of T lymphocytes, plays an important role in autoimmune disorders and inflammatory diseases. MATERIAL AND METHODS This study explored the role of different lymphocyte subsets in chronic ITP. To explore the value of Th22 cells in the diagnosis of ITP, the numbers of Th1, Th17, and Th22 cells were detected by a 4-color flow cytometric in 32 chronic ITP patients and 30 healthy controls. RESULTS Our data showed that, compared with healthy controls, the numbers of circulating Th1, Th17, and Th22 (p<0.05) cells increased significantly in ITP patients, and Th22 cells were correlated positively with Th1 cells (r=0.4041, p<0.01) and Th17 cells (r=0.4637, p<0.05). Moreover, a positive relationship was found between Th1/Th22 cells and Th1 cells (r=0.7696, p<0.001). CONCLUSIONS A disequilibrium expression profile of Th22 cells in peripheral blood was associated with pathogenesis of ITP, possibly through cooperatively working with Th17 and Th1, which may provide a novel approach for diagnosis of ITP.

Citing Articles

Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases.

Jiang Q, Yang G, Xiao F, Xie J, Wang S, Lu L Front Immunol. 2021; 12:688066.

PMID: 34295334 PMC: 8290841. DOI: 10.3389/fimmu.2021.688066.

[The role of helper T cell in the pathogenesis of osteoarthritis].

Yang D, Zhang Z Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020; 34(7):932-938.

PMID: 32666741 PMC: 8180432. DOI: 10.7507/1002-1892.201910063.

Advances in the role of helper T cells in autoimmune diseases.

Zhang X, Liu C, Shao Z Chin Med J (Engl). 2020; 133(8):968-974.

PMID: 32187054 PMC: 7176439. DOI: 10.1097/CM9.0000000000000748.

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