Temperature Sensing Is Distributed Throughout the Regulatory Network That Controls FLC Epigenetic Silencing in Vernalization

Overview

Journal Cell Syst

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2018 Dec 4

PMID 30503646

Citations 24

Authors

Rea L Antoniou-Kourounioti

Jo Hepworth

Amelie Heckmann

Susan Duncan

Julia Questa

Stefanie Rosa

Torbjorn Sall

Svante Holm

Caroline Dean

Martin Howard

Affiliations

Soon will be listed here.

Abstract

Many organisms need to respond to complex, noisy environmental signals for developmental decision making. Here, we dissect how Arabidopsis plants integrate widely fluctuating field temperatures over month-long timescales to progressively upregulate VERNALIZATION INSENSITIVE3 (VIN3) and silence FLOWERING LOCUS C (FLC), aligning flowering with spring. We develop a mathematical model for vernalization that operates on multiple timescales-long term (month), short term (day), and current (hour)-and is constrained by experimental data. Our analysis demonstrates that temperature sensing is not localized to specific nodes within the FLC network. Instead, temperature sensing is broadly distributed, with each thermosensory process responding to specific features of the plants' history of exposure to warm and cold. The model accurately predicts FLC silencing in new field data, allowing us to forecast FLC expression in changing climates. We suggest that distributed thermosensing may be a general property of thermoresponsive regulatory networks in complex natural environments.

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