Toward Exosome-Based Neuronal Diagnostic Devices

Overview

Journal Micromachines (Basel)

Publisher MDPI

Date 2018 Dec 2

PMID 30501125

Citations 16

Authors

Yong Kyoung Yoo

Junwoo Lee

Hyungsuk Kim

Kyo Seon Hwang

Dae Sung Yoon

Jeong Hoon Lee

Affiliations

Soon will be listed here.

Abstract

Targeting exosome for liquid biopsy has gained significant attention for its diagnostic and therapeutic potential. For detecting neuronal disease diagnosis such as Alzheimer's disease (AD), the main technique for identifying AD still relies on positron-emission tomography (PET) imaging to detect the presence of amyloid-β (Aβ). While the detection of Aβ in cerebrospinal fluid has also been suggested as a marker for AD, the lack of quantitative measurements has compromised existing assays. In cerebrospinal fluid, in addition to Aβ, T-Tau, and P-Tau, alpha-synuclein has been considered a biomarker of neurodegeneration. This review suggests that and explains how the exosome can be used as a neuronal diagnostic component. To this end, we summarize current progress in exosome preparation/isolation and quantification techniques and comment on the outlooks for neuronal exosome-based diagnostic techniques.

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