Annexins in Influenza Virus Replication and Pathogenesis

Overview

Journal Front Pharmacol

Date 2018 Dec 1

PMID 30498445

Citations 12

Authors

Patrick Baah Ampomah

Wan Ting Kong

Olga Zharkova

Sonja C J H Chua

R Perumal Samy

Lina H K Lim

Affiliations

Soon will be listed here.

Abstract

Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and respiratory distress syndrome. Treatment of IAV infections is complicated because the virus can evade host immunity through antigenic drifts and antigenic shifts, to establish infections making new treatment options desirable. Annexins (ANXs) are a family of calcium and phospholipid binding proteins with immunomodulatory roles in viral infections, lung injury, and inflammation. A current understanding of the role of ANXs in modulating IAV infection and host responses will enable the future development of more effective antiviral therapies. This review presents a comprehensive understanding of the advances made in the field of ANXs, in particular, ANXA1 and IAV research and highlights the importance of ANXs as a suitable target for IAV therapy.

Citing Articles

Gene expression profiling in PBMCs for acute rejection in lung transplant recipients reveals myeloid responses.

Liu S, Westra J, Hu S, Verschuuren E, van Kempen L, van Baarle D Front Transplant. 2025; 3:1508419.

PMID: 39744543 PMC: 11688322. DOI: 10.3389/frtra.2024.1508419.

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection.

Bahojb Mahdavi S, Jebelli A, Aghbash P, Baradaran B, Amini M, Oroojalian F Med Res Rev. 2024; 45(2):349-425.

PMID: 39185567 PMC: 11796338. DOI: 10.1002/med.22073.

GENIX enables comparative network analysis of single-cell RNA sequencing to reveal signatures of therapeutic interventions.

Nouri N, Gaglia G, Mattoo H, de Rinaldis E, Savova V Cell Rep Methods. 2024; 4(6):100794.

PMID: 38861988 PMC: 11228368. DOI: 10.1016/j.crmeth.2024.100794.

Predictive Value of Annenxin A1 for Disease Severity and Prognosis in Patients with Community-Acquired Pneumonia.

Gu M, Han X, Liu X, Sui F, Zhang Q, Pan S Diagnostics (Basel). 2023; 13(3).

PMID: 36766501 PMC: 9914428. DOI: 10.3390/diagnostics13030396.

Chronic Exposure to the Food Additive tBHQ Modulates Expression of Genes Related to SARS-CoV-2 and Influenza Viruses.

Nemeth K, Petschner P, Paloczi K, Fekete N, Pallinger E, Buzas E Life (Basel). 2022; 12(5).

PMID: 35629310 PMC: 9147452. DOI: 10.3390/life12050642.

References

Mata M, Satterly N, Versteeg G, Frantz D, Wei S, Williams N . Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Nat Chem Biol. 2011; 7(10):712-9. PMC: 3329801. DOI: 10.1038/nchembio.645. View

Zhirnov O, Klenk H . Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis. 2007; 12(8):1419-32. DOI: 10.1007/s10495-007-0071-y. View

Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y . Identification of novel influenza A virus proteins translated from PA mRNA. J Virol. 2012; 87(5):2455-62. PMC: 3571384. DOI: 10.1128/JVI.02656-12. View

Ma H, Kien F, Maniere M, Zhang Y, Lagarde N, Tse K . Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection. J Virol. 2011; 86(3):1789-801. PMC: 3264383. DOI: 10.1128/JVI.06003-11. View

Huggins A, Paschalidis N, Flower R, Perretti M, DAcquisto F . Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. FASEB J. 2008; 23(4):985-96. DOI: 10.1096/fj.08-119040. View

Lim L, Solito E, Flower R, Perretti M . Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998; 95(24):14535-9. PMC: 24408. DOI: 10.1073/pnas.95.24.14535. View

Cooray S, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark A . Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A. 2013; 110(45):18232-7. PMC: 3831442. DOI: 10.1073/pnas.1308253110. View

Schloer S, Pajonczyk D, Rescher U . Annexins in Translational Research: Hidden Treasures to Be Found. Int J Mol Sci. 2018; 19(6). PMC: 6032224. DOI: 10.3390/ijms19061781. View

Ampomah P, Moraes L, Lukman H, Lim L . Formyl peptide receptor 2 is regulated by RNA mimics and viruses through an IFN-β-STAT3-dependent pathway. FASEB J. 2017; 32(3):1468-1478. DOI: 10.1096/fj.201700584RR. View

10.

Serhan C . Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014; 510(7503):92-101. PMC: 4263681. DOI: 10.1038/nature13479. View

11.

Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A . Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections. J Infect Dis. 2016; 214(2):237-47. DOI: 10.1093/infdis/jiw127. View

12.

Perretti M, Ahluwalia A, Harris J, HARRIS H, Wheller S, Flower R . Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. Br J Pharmacol. 1996; 117(6):1145-54. PMC: 1909779. DOI: 10.1111/j.1476-5381.1996.tb16709.x. View

13.

Walther A, Riehemann K, Gerke V . A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000; 5(5):831-40. DOI: 10.1016/s1097-2765(00)80323-8. View

14.

Rescher U, Gerke V . Annexins--unique membrane binding proteins with diverse functions. J Cell Sci. 2004; 117(Pt 13):2631-9. DOI: 10.1242/jcs.01245. View

15.

Morimoto K, Janssen W, Fessler M, McPhillips K, Borges V, Bowler R . Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J Immunol. 2006; 176(12):7657-65. DOI: 10.4049/jimmunol.176.12.7657. View

16.

Cirino G, Cicala C, Sorrentino L, Ciliberto G, Arpaia G, Perretti M . Anti-inflammatory actions of an N-terminal peptide from human lipocortin 1. Br J Pharmacol. 1993; 108(3):573-4. PMC: 1908051. DOI: 10.1111/j.1476-5381.1993.tb12843.x. View

17.

Williams S, Milne I, Bagley C, Gamble J, Vadas M, Pitson S . A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration. J Immunol. 2010; 185(5):3057-63. DOI: 10.4049/jimmunol.1000119. View

18.

Buckley C, Gilroy D, Serhan C . Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity. 2014; 40(3):315-27. PMC: 4004957. DOI: 10.1016/j.immuni.2014.02.009. View

19.

Enrich C, Rentero C, Vila de Muga S, Reverter M, Mulay V, Wood P . Annexin A6-Linking Ca(2+) signaling with cholesterol transport. Biochim Biophys Acta. 2010; 1813(5):935-47. DOI: 10.1016/j.bbamcr.2010.09.015. View

20.

Barnig C, Cernadas M, Dutile S, Liu X, Perrella M, Kazani S . Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013; 5(174):174ra26. PMC: 3823369. DOI: 10.1126/scitranslmed.3004812. View