Noncoding RNAs in Multiple Sclerosis

Overview

Journal Clin Epigenetics

Publisher Biomed Central

Specialty Genetics

Date 2018 Dec 1

PMID 30497529

Citations 23

Authors

Xuan Yang

Yuzhang Wu

Bei Zhang

Bing Ni

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is characterized by axonal degeneration and gliosis. Although the causes of MS remain unknown, gene dysregulation in the central nervous system has been associated with the disease pathogenesis. As such, the various regulators of gene expression may be contributing factors. The noncoding (nc) RNAs have piqued the interest of MS researchers due to their known functions in human physiology and various pathological processes, despite being generally characterized as transcripts without apparent protein-coding capacity. Accumulating evidence has indicated that ncRNAs participate in the regulation of MS by acting as epigenetic factors, especially the long (l) ncRNAs and the micro (mi) RNAs, and they are now recognized as key regulatory molecules in MS. In this review, we summarize the most current studies on the contribution of ncRNAs in MS pathogenic processes and discuss their potential applications in the diagnosis and treatment of MS.

Citing Articles

Biological functions and affected signaling pathways by Long Non-Coding RNAs in the immune system.

Ghahramani Almanghadim H, Karimi B, Valizadeh S, Ghaedi K Noncoding RNA Res. 2024; 10:70-90.

PMID: 39315339 PMC: 11417496. DOI: 10.1016/j.ncrna.2024.09.001.

Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways.

Cipriano G, Schepici G, Mazzon E, Anchesi I Int J Mol Sci. 2024; 25(4).

PMID: 38396932 PMC: 10889752. DOI: 10.3390/ijms25042255.

Circular RNA in Multiple Sclerosis: Pathogenicity and Potential Biomarker Development: A Systematic Review.

Mohammed E Epigenet Insights. 2023; 16:25168657231213195.

PMID: 38033465 PMC: 10687999. DOI: 10.1177/25168657231213195.

Transcriptome driven discovery of novel candidate genes for human neurological disorders in the telomer-to-telomer genome assembly era.

Falker-Gieske C Hum Genomics. 2023; 17(1):94.

PMID: 37872607 PMC: 10594789. DOI: 10.1186/s40246-023-00543-y.

MicroRNA‑155 modulation of CD8 T‑cell activity personalizes response to disease‑modifying therapies of patients with relapsing‑remitting multiple sclerosis.

Elkhodiry A, Zamzam D, El Tayebi H Med Int (Lond). 2023; 3(2):20.

PMID: 37032715 PMC: 10080195. DOI: 10.3892/mi.2023.80.

References

Otaegui D, Baranzini S, Armananzas R, Calvo B, Munoz-Culla M, Khankhanian P . Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS One. 2009; 4(7):e6309. PMC: 2708922. DOI: 10.1371/journal.pone.0006309. View

Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E . Matrix metalloproteinases degrade myelin basic protein. Neurosci Lett. 1995; 201(3):223-6. DOI: 10.1016/0304-3940(95)12173-0. View

Dutta R, Chomyk A, Chang A, Ribaudo M, Deckard S, Doud M . Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol. 2013; 73(5):637-45. PMC: 3679350. DOI: 10.1002/ana.23860. View

Hiltensperger M, Korn T . The Interleukin (IL)-23/T helper (Th)17 Axis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Cold Spring Harb Perspect Med. 2017; 8(1). PMC: 5749145. DOI: 10.1101/cshperspect.a029637. View

Colombo T, Farina L, Macino G, Paci P . PVT1: a rising star among oncogenic long noncoding RNAs. Biomed Res Int. 2015; 2015:304208. PMC: 4391155. DOI: 10.1155/2015/304208. View

Calin G, Sevignani C, Dumitru C, Hyslop T, Noch E, Yendamuri S . Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004; 101(9):2999-3004. PMC: 365734. DOI: 10.1073/pnas.0307323101. View

Iparraguirre L, Munoz-Culla M, Prada-Luengo I, Castillo-Trivino T, Olascoaga J, Otaegui D . Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. Hum Mol Genet. 2017; 26(18):3564-3572. DOI: 10.1093/hmg/ddx243. View

Wu G, Pan H, Leng R, Wang D, Li X, Li X . Emerging role of long noncoding RNAs in autoimmune diseases. Autoimmun Rev. 2015; 14(9):798-805. DOI: 10.1016/j.autrev.2015.05.004. View

Bergman P, Piket E, Khademi M, James T, Brundin L, Olsson T . Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016; 3(3):e219. PMC: 4841644. DOI: 10.1212/NXI.0000000000000219. View

10.

Han B, Chao J, Yao H . Circular RNA and its mechanisms in disease: From the bench to the clinic. Pharmacol Ther. 2018; 187:31-44. DOI: 10.1016/j.pharmthera.2018.01.010. View

11.

Montagner S, Deho L, Monticelli S . MicroRNAs in hematopoietic development. BMC Immunol. 2014; 15:14. PMC: 4000146. DOI: 10.1186/1471-2172-15-14. View

12.

Escobar T, Kanellopoulou C, Kugler D, Kilaru G, Nguyen C, Nagarajan V . miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 2014; 40(6):865-79. PMC: 4092165. DOI: 10.1016/j.immuni.2014.03.014. View

13.

Liu Q, Gao Q, Zhang Y, Li Z, Mei X . MicroRNA-590 promotes pathogenic Th17 cell differentiation through targeting Tob1 and is associated with multiple sclerosis. Biochem Biophys Res Commun. 2017; 493(2):901-908. DOI: 10.1016/j.bbrc.2017.09.123. View

14.

Asahi M, Wang X, Mori T, Sumii T, Jung J, Moskowitz M . Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001; 21(19):7724-32. PMC: 6762894. View

15.

OConnell R, Kahn D, Gibson W, Round J, Scholz R, Chaudhuri A . MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity. 2010; 33(4):607-19. PMC: 2966521. DOI: 10.1016/j.immuni.2010.09.009. View

16.

Lewis B, Burge C, Bartel D . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005; 120(1):15-20. DOI: 10.1016/j.cell.2004.12.035. View

17.

Costa F . Non-coding RNAs: Meet thy masters. Bioessays. 2010; 32(7):599-608. DOI: 10.1002/bies.200900112. View

18.

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A . Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013; 495(7441):333-8. DOI: 10.1038/nature11928. View

19.

Wright M, Bruford E . Naming 'junk': human non-protein coding RNA (ncRNA) gene nomenclature. Hum Genomics. 2011; 5(2):90-8. PMC: 3051107. DOI: 10.1186/1479-7364-5-2-90. View

20.

Hintzen R, van Pelt D . Paediatric MS is the same disease as adult MS: yes. Mult Scler. 2013; 19(10):1257-8. DOI: 10.1177/1352458513490548. View