Genomics, Microbiomics, Proteomics, and Metabolomics in Bronchopulmonary Dysplasia

Overview

Journal Semin Perinatol

Specialty Gynecology & Obstetrics

Date 2018 Nov 30

PMID 30487069

Citations 18

Authors

Charitharth Vivek Lal

Vineet Bhandari

Namasivayam Ambalavanan

Affiliations

Soon will be listed here.

Abstract

Bronchopulmonary Dysplasia (BPD) is a disorder with a multifactorial etiology and highly variable clinical phenotype. Several traditional biomarkers have been identified, but due to the complex disease phenotype, these biomarkers have low predictive accuracy for BPD. In recent years, newer technologies have facilitated the in-depth and unbiased analysis of 'big data' in delineating the diagnosis, pathogenesis, and mechanisms of diseases. Novel systems-biology based 'omic' approaches, including but not limited to genomics, microbiomics, proteomics, and metabolomics may help define the multiple cellular and humoral interactions that regulate normal as well as abnormal lung development and response to injury that are the hallmarks of BPD.

Citing Articles

The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach.

Valerio E, Meneghelli M, Stocchero M, Galderisi A, Visentin S, Bonadies L Int J Mol Sci. 2024; 25(11).

PMID: 38892043 PMC: 11172597. DOI: 10.3390/ijms25115860.

A bioinformatics approach towards bronchopulmonary dysplasia.

Valadie C, Arya S, Arora T, Pandillapalli N, Moreira A Transl Pediatr. 2023; 12(6):1213-1224.

PMID: 37427053 PMC: 10326754. DOI: 10.21037/tp-23-133.

Development of a blood proteins-based model for bronchopulmonary dysplasia prediction in premature infants.

Ou W, Lei K, Wang H, Ma H, Deng X, He P BMC Pediatr. 2023; 23(1):304.

PMID: 37330491 PMC: 10276448. DOI: 10.1186/s12887-023-04065-3.

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?.

Cui X, Fu J ERJ Open Res. 2023; 9(2).

PMID: 37020839 PMC: 10068511. DOI: 10.1183/23120541.00621-2022.

Exploring the "gene-protein-metabolite" network of coronary heart disease with phlegm and blood stasis syndrome by integrated multi-omics strategy.

Yang G, Zhou S, He H, Shen Z, Liu Y, Hu J Front Pharmacol. 2022; 13:1022627.

PMID: 36523490 PMC: 9744761. DOI: 10.3389/fphar.2022.1022627.

References

Justino P, Melo L, Nogueira A, Morais C, Mendes W, Franco A . Regulatory role of Lactobacillus acidophilus on inflammation and gastric dysmotility in intestinal mucositis induced by 5-fluorouracil in mice. Cancer Chemother Pharmacol. 2015; 75(3):559-67. DOI: 10.1007/s00280-014-2663-x. View

Wishart D . Emerging applications of metabolomics in drug discovery and precision medicine. Nat Rev Drug Discov. 2016; 15(7):473-84. DOI: 10.1038/nrd.2016.32. View

Hagood J, Ambalavanan N . Systems biology of lung development and regeneration: current knowledge and recommendations for future research. Wiley Interdiscip Rev Syst Biol Med. 2013; 5(2):125-33. DOI: 10.1002/wsbm.1205. View

Parker R, Lindstrom D, Cotton R . Evidence from twin study implies possible genetic susceptibility to bronchopulmonary dysplasia. Semin Perinatol. 1996; 20(3):206-9. DOI: 10.1016/s0146-0005(96)80049-8. View

Sagar S, Morgan M, Chen S, Vos A, Garssen J, van Bergenhenegouwen J . Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma. Respir Res. 2014; 15:46. PMC: 4029990. DOI: 10.1186/1465-9921-15-46. View

Lavoie P, Pham C, Jang K . Heritability of bronchopulmonary dysplasia, defined according to the consensus statement of the national institutes of health. Pediatrics. 2008; 122(3):479-85. PMC: 4631604. DOI: 10.1542/peds.2007-2313. View

Hamvas A, Deterding R, Balch W, Schwartz D, Albertine K, Whitsett J . Diffuse lung disease in children: summary of a scientific conference. Pediatr Pulmonol. 2013; 49(4):400-9. PMC: 4145861. DOI: 10.1002/ppul.22805. View

Salaets T, Richter J, Brady P, Jimenez J, Nagatomo T, Deprest J . Transcriptome Analysis of the Preterm Rabbit Lung after Seven Days of Hyperoxic Exposure. PLoS One. 2015; 10(8):e0136569. PMC: 4552674. DOI: 10.1371/journal.pone.0136569. View

Ursell L, Metcalf J, Parfrey L, Knight R . Defining the human microbiome. Nutr Rev. 2012; 70 Suppl 1:S38-44. PMC: 3426293. DOI: 10.1111/j.1753-4887.2012.00493.x. View

10.

Pietrzyk J, Kwinta P, Wollen E, Bik-Multanowski M, Madetko-Talowska A, Gunther C . Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development. PLoS One. 2013; 8(10):e78585. PMC: 3806835. DOI: 10.1371/journal.pone.0078585. View

11.

Kho A, Chhabra D, Sharma S, Qiu W, Carey V, Gaedigk R . Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome. Am J Respir Cell Mol Biol. 2015; 54(6):814-21. PMC: 4942221. DOI: 10.1165/rcmb.2015-0326OC. View

12.

Sylvester K, Ling X, Yuen-Gee Liu G, Kastenberg Z, Ji J, Hu Z . Urine protein biomarkers for the diagnosis and prognosis of necrotizing enterocolitis in infants. J Pediatr. 2014; 164(3):607-12.e1-7. PMC: 4161235. DOI: 10.1016/j.jpeds.2013.10.091. View

13.

Mu J, Pang Q, Guo Y, Chen J, Zeng W, Huang Y . Functional implications of microRNA-215 in TGF-β1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1. PLoS One. 2013; 8(3):e58622. PMC: 3595285. DOI: 10.1371/journal.pone.0058622. View

14.

Nardiello C, Morty R . MicroRNA in late lung development and bronchopulmonary dysplasia: the need to demonstrate causality. Mol Cell Pediatr. 2016; 3(1):19. PMC: 4877338. DOI: 10.1186/s40348-016-0047-5. View

15.

Lal C, Schwarz M . Vascular mediators in chronic lung disease of infancy: role of endothelial monocyte activating polypeptide II (EMAP II). Birth Defects Res A Clin Mol Teratol. 2014; 100(3):180-8. PMC: 4280095. DOI: 10.1002/bdra.23234. View

16.

Lal C, Travers C, Aghai Z, Eipers P, Jilling T, Halloran B . The Airway Microbiome at Birth. Sci Rep. 2016; 6:31023. PMC: 4973241. DOI: 10.1038/srep31023. View

17.

Magagnotti C, Matassa P, Bachi A, Vendettuoli V, Fermo I, Colnaghi M . Calcium signaling-related proteins are associated with broncho-pulmonary dysplasia progression. J Proteomics. 2013; 94:401-12. DOI: 10.1016/j.jprot.2013.10.007. View

18.

Ambalavanan N, Cotten C, Page G, Carlo W, Murray J, Bhattacharya S . Integrated genomic analyses in bronchopulmonary dysplasia. J Pediatr. 2014; 166(3):531-7.e13. PMC: 4344889. DOI: 10.1016/j.jpeds.2014.09.052. View

19.

Hadchouel A, Durrmeyer X, Bouzigon E, Incitti R, Huusko J, Jarreau P . Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2011; 184(10):1164-70. PMC: 4826668. DOI: 10.1164/rccm.201103-0548OC. View

20.

Cho H, Van Houten B, Wang X, Miller-DeGraff L, Fostel J, Gladwell W . Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice. Antioxid Redox Signal. 2012; 17(8):1066-82. PMC: 3423869. DOI: 10.1089/ars.2011.4288. View