Sequence Requirements for Nucleolar Localization of Human T Cell Leukemia Virus Type I PX Protein, Which Regulates Viral RNA Processing

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 1988 Oct 21

PMID 3048703

Citations 142

Authors

H Siomi

H Shida

S H Nam

T Nosaka

M Maki

M Hatanaka

Affiliations

Soon will be listed here.

Abstract

The posttranscriptional regulator (p27x-III) of human T cell leukemia virus type I (HTLV-I) is located predominantly in the cell nucleolus. A highly basic amino-terminal sequence (NH2-Met-Pro-Lys-Thr-Arg-Arg-Arg-Pro-Arg-Arg-Ser-Gln-Arg-Lys-Arg-Pro-Pro -Thr- Pro) in this protein, when fused to the amino termini of beta-galactosidase and p40x of HTLV-I, acts as an autonomous signal capable of directing the hybrid proteins to the cell nucleolus.

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