Nuclear Trafficking of Retroviral RNAs and Gag Proteins During Late Steps of Replication

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2013 Nov 21

PMID 24253283

Citations 21

Authors

Matthew S Stake

Darrin V Bann

Rebecca J Kaddis

Leslie J Parent

Affiliations

Soon will be listed here.

Abstract

Retroviruses exploit nuclear trafficking machinery at several distinct stages in their replication cycles. In this review, we will focus primarily on nucleocytoplasmic trafficking events that occur after the completion of reverse transcription and proviral integration. First, we will discuss nuclear export of unspliced viral RNA transcripts, which serves two essential roles: as the mRNA template for the translation of viral structural proteins and as the genome for encapsidation into virions. These full-length viral RNAs must overcome the cell's quality control measures to leave the nucleus by co-opting host factors or encoding viral proteins to mediate nuclear export of unspliced viral RNAs. Next, we will summarize the most recent findings on the mechanisms of Gag nuclear trafficking and discuss potential roles for nuclear localization of Gag proteins in retrovirus replication.

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