Recent Advances in the Use of Model to Study Immune Responses Against Human Pathogens

Overview

Journal J Fungi (Basel)

Date 2018 Nov 30

PMID 30486393

Citations 80

Authors

Thais Cristine Pereira

Patricia Pimentel de Barros

Luciana Ruano de Oliveira Fugisaki

Rodnei Dennis Rossoni

Felipe de Camargo Ribeiro

Raquel Teles de Menezes

Juliana Campos Junqueira

Liliana Scorzoni

Affiliations

Soon will be listed here.

Abstract

The use of invertebrates for in vivo studies in microbiology is well established in the scientific community. Larvae of are a widely used model for studying pathogenesis, the efficacy of new antimicrobial compounds, and immune responses. The immune system of larvae is structurally and functionally similar to the innate immune response of mammals, which makes this model suitable for such studies. In this review, cellular responses (hemocytes activity: phagocytosis, nodulation, and encapsulation) and humoral responses (reactions or soluble molecules released in the hemolymph as antimicrobial peptides, melanization, clotting, free radical production, and primary immunization) are discussed, highlighting the use of as a model of immune response to different human pathogenic microorganisms.

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