Modeling Craniofacial Development Reveals Spatiotemporal Constraints on Robust Patterning of the Mandibular Arch

Overview

Journal PLoS Comput Biol

Specialty Biology

Date 2018 Nov 28

PMID 30481168

Citations 8

Authors

Lina Meinecke

Praveer P Sharma

Huijing Du

Lei Zhang

Qing Nie

Thomas F Schilling

Affiliations

Soon will be listed here.

Abstract

How does pattern formation occur accurately when confronted with tissue growth and stochastic fluctuations (noise) in gene expression? Dorso-ventral (D-V) patterning of the mandibular arch specifies upper versus lower jaw skeletal elements through a combination of Bone morphogenetic protein (Bmp), Endothelin-1 (Edn1), and Notch signaling, and this system is highly robust. We combine NanoString experiments of early D-V gene expression with live imaging of arch development in zebrafish to construct a computational model of the D-V mandibular patterning network. The model recapitulates published genetic perturbations in arch development. Patterning is most sensitive to changes in Bmp signaling, and the temporal order of gene expression modulates the response of the patterning network to noise. Thus, our integrated systems biology approach reveals non-intuitive features of the complex signaling system crucial for craniofacial development, including novel insights into roles of gene expression timing and stochasticity in signaling and gene regulation.

Citing Articles

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