Blood and Thyroid-infiltrating Lymphocyte Subclasses in Juvenile Autoimmune Thyroiditis

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1977 Nov 1

PMID 304781

Citations 6

Authors

T H Totterman

J Maenpaa

A Gordin

T Makinen

E Taskinens

L C Andersson

P Hayry

Affiliations

Soon will be listed here.

Abstract

We have studied the distribution of T and B lymphocytes in the blood and in the thyroid lymphocytic infiltrates (obtained by fine needle aspiration biopsy) in sixteen patients with juvenile autoimmune thyroiditis (JAIT). The same cell populations were also tested for cell-mediated immunity (CMI) to thyroid antigen in the leucocyte migration test (LMT). The relative and absolute numbers of blood T lymphocytes were normal (71-76%), as were the numbers of blood B lymphocytes (19%). The thyroid infiltrate contained 48% B lymphocytes, whereas only 40-44% of the infiltrating lymphocytes were T cells. Half of the JAIT patients showed a positive CMI to thyroid antigen with blood leucocytes, but when thyroid-infiltrating lymphocytes of these patients were tested in the LMT, they were negative. Thus, in contrast to what is generally assumed, we were unable to demonstrate T cell-dominated lymphocytic infiltrates or the accumulation of specifically sensitized T lymphocytes within the thyroid gland in autoimmune thyroiditis.

Citing Articles

Impairment of regulatory T-cell function in autoimmune thyroid disease.

Glick A, Wodzinski A, Fu P, Levine A, Wald D Thyroid. 2013; 23(7):871-8.

PMID: 23379353 PMC: 3704106. DOI: 10.1089/thy.2012.0514.

Increase of peripheral B lymphocytes in Graves' disease.

Mori H, Amino N, Iwatani Y, Kabutomori O, Asari S, Motoi S Clin Exp Immunol. 1980; 42(1):33-40.

PMID: 6970099 PMC: 1537063.

Leukocyte migration test (LMT) in patients with thyroid disease: the response to human thyroid subcellular fractions.

Galluzzo A, Filardo C, Giordano C, Sparacino G, BOMPIANI G J Endocrinol Invest. 1981; 4(2):173-6.

PMID: 6895083 DOI: 10.1007/BF03350447.

Immunological events leading to destructive thyroiditis in the AUG rat.

Hassman R, Solic N, Jasani B, Hall R, McGregor A Clin Exp Immunol. 1988; 73(3):410-6.

PMID: 3208452 PMC: 1541757.

Cells infiltrating the thyroid in juvenile autoimmune thyroiditis.

Kontiainen S, Lautenschlager I, Nyberg M, Maenpaa J Clin Exp Immunol. 1987; 67(1):89-94.

PMID: 2957132 PMC: 1542560.

References

Doniach D, NILSSON L, Roitt I . AUTOIMMUNE THYROIDITIS IN CHILDREN AND ADOLESCENTS. II. IMMUNOLOGICAL CORRELATIONS AND PARENT STUDY. Acta Paediatr Scand. 1965; 54:260-74. DOI: 10.1111/j.1651-2227.1965.tb06369.x. View

Roitt I, Doniach D . Human autoimmune thyroiditis: serological studies. Lancet. 1958; 2(7055):1027-33. DOI: 10.1016/s0140-6736(58)90530-0. View

Ranki A, Totterman T, Hayry P . Identification of resting human T and B lymphocytes by acid alpha-naphthyl acetate esterase staining combined with rosette formation with Staphylococcus aureus strain Cowan 1. Scand J Immunol. 1976; 5(10):1129-38. DOI: 10.1111/j.1365-3083.1976.tb00254.x. View

Makinen T, Totterman T, Gordin A, Weber T . Migration inhibition factor and the blood clotting system: effects of defibrination, heparin and thrombin. Clin Exp Immunol. 1977; 29(1):181-6. PMC: 1541032. View

Hayry P, Totterman T, Ranki A . Lack of subclass selection during density purification of human lymphocytes. Clin Exp Immunol. 1977; 28(2):341-6. PMC: 1540756. View

Totterman T, Makinen T, Gordin A . Cell-mediated autoimmunity in thyroid disease as studied by the leukocyte migration test; correlation to clinical state and effect of treatment. Acta Endocrinol (Copenh). 1977; 86(1):89-98. DOI: 10.1530/acta.0.0860089. View

Hackenberg K, Cohnen G, REINWEIN D . [T-cells in thyroid disease (author's transl)]. Klin Wochenschr. 1976; 54(20):987-93. DOI: 10.1007/BF01468950. View

Mueller J, Brun del Re G, Buerki H, Keller H, Hess M, COTTIER H . Nonspecific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes. Eur J Immunol. 1975; 5(4):270-4. DOI: 10.1002/eji.1830050411. View

Calder E, Irvine W, Davidson N, Wu F . T, B and K cells in autoimmune thyroid disease. Clin Exp Immunol. 1976; 25(1):17-22. PMC: 1541376. View

10.

Basten A, Miller J, Sprent J, Pye J . A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J Exp Med. 1972; 135(3):610-26. PMC: 2139129. DOI: 10.1084/jem.135.3.610. View

11.

Perrin J, Bubel M . Assessment of a haemagglutination test for thyroid microsomal antibody. Med Lab Technol. 1974; 31(3):205-11. View

12.

. Organization of the invading lymphoid tissue in human lymphoid thyroiditis. Scand J Immunol. 1974; 3(3):295-301. DOI: 10.1111/j.1365-3083.1974.tb01260.x. View

13.

Loeb P, Drash A, KENNY F . Prevalence of low-titer and "negative" antithyroglobulin antibodies in biopsy-proved juvenile Hashimoto's thyroiditis. J Pediatr. 1973; 82(1):17-21. DOI: 10.1016/s0022-3476(73)80004-6. View

14.

Aoki N, WAKISAKA G, Nagata I . Increase of T cells in Graves' disease. Lancet. 1973; 2(7819):49-50. DOI: 10.1016/s0140-6736(73)91993-4. View

15.

Farid N, Munro R, Row V, Volpe R . Peripheral thymus-dependent (T) lymphocytes in Graves's disease and Hashimoto's thyroiditis. N Engl J Med. 1973; 288(25):1313-7. DOI: 10.1056/NEJM197306212882502. View

16.

Maenpaa J . Juvenile goitrous autoimmune thyroiditis. Acta Paediatr Scand. 1972; 61(1):49-62. DOI: 10.1111/j.1651-2227.1972.tb15902.x. View

17.

Pellegrino M, Ferrone S, Dierich M, Reisfeld R . Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide. Clin Immunol Immunopathol. 1975; 3(3):324-33. DOI: 10.1016/0090-1229(75)90019-7. View

18.

Holdaway I, Rees L, Ratcliffe J, Besser G, KRAMER R . Validation of the redox cytochemical assay for corticotrophin. Clin Endocrinol (Oxf). 1974; 3(3):329-34. DOI: 10.1111/j.1365-2265.1974.tb01806.x. View

19.

Rallison M, DOBYNS B, KEATING F, RALL J, TYLER F . Occurrence and natural history of chronic lymphocytic thyroiditis in childhood. J Pediatr. 1975; 86(5):675-82. DOI: 10.1016/s0022-3476(75)80350-7. View

20.

Urbaniak S, Penhale W, Irvine W . Peripheral blood T and B lymphocytes in patients with thyrotoxicosis and Hashimoto's thyroiditis and in normal subjects. A comparison of lymphocyte separation methods. Clin Exp Immunol. 1974; 18(4):449-59. PMC: 1538007. View