Platelet Count on Preoperative Day 1 Predicts the Long-term Responses to Laparoscopic Splenectomy for Chinese Patients with Medically Refractory Idiopathic Thrombocytopenic Purpura

Overview

Journal BMC Surg

Publisher Biomed Central

Specialty General Surgery

Date 2018 Nov 28

PMID 30477462

Citations 4

Authors

Rui Liao

Pei-Yuan Tang

Jun-Feng Song

Ke-Le Qin

Xun Wang

Xiong Yan

Affiliations

Soon will be listed here.

Abstract

Background: Laparoscopic splenectomy (LS) is regarded as a second-line treatment for medically refractory idiopathic thrombocytopenic purpura (ITP), but the predictive factors for the long-term postoperative responses to ITP are still a matter of debate. We aimed to investigate the factors that can predict the long-term response after LS for Chinese patients with medically refractory ITP.

Methods: From January 2011 to September 2016, 78 Chinese patients with ITP who underwent LS were retrospectively analyzed. Twelve parameters were analyzed by univariate and multivariate methods.

Results: Univariate analysis revealed that platelet count on preoperative day (PRD) 1 (P < 0.001) and operative time (P = 0.011) were significantly associated with long-term response of ITP after LS. Multivariate analysis revealed that platelet count on PRD 1 was a predictive factor of long-term response (P < 0.001). Furthermore, a long-term, stable response of platelet count on PRD 1 of > 30.0 × 10/L was easier to achieve than a platelet count on PRD 1 ≤ 30.0 × 10/L after LS for ITP.

Conclusions: LS is a valuable and effective option in the treatment of medically refractory ITP. Platelet count on PRD 1 is an independent predicting factor for long-term response after LS for Chinese patients with ITP.

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