Predictive Factors Associated with Long-term Effects of Laparoscopic Splenectomy for Chronic Immune Thrombocytopenia

Overview

Journal Int J Hematol

Specialty Hematology

Date 2013 Apr 18

PMID 23591716

Citations 8

Authors

Mingjun Wang

Mengni Zhang

Jin Zhou

Zhong Wu

Ke Zeng

Bing Peng

Ting Niu

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate the long-term effects of laparoscopic splenectomy (LS) for patients with chronic immune thrombocytopenia (ITP), and to identify predictive factors for promising hematological outcomes. We retrospectively analyzed the clinical records and follow-up data in patients who underwent LS for chronic ITP from November 2005 to August 2012. The related parameters were assessed by univariate and multivariate logistic regression analyses. The curve of life table was drawn to clarify the long-term response rate. Of the 92 included patients, 49 (53.3 %) patients achieved a complete response, 21 patients (22.8 %) a partial response, and the remaining 22 (23.9 %) showed no response to LS. Eleven patients relapsed within 1 year after LS, especially within 3 months (n = 7), while three patients relapsed 17, 26, and 28 months after LS, respectively. Long-term specific complications after LS were not observed. Platelet counts on postoperative month 3 (POM 3) is a significant independent predictor of long-term favorable hematological outcomes (P < 0.001). Based on our study, we conclude that LS is associated with promising long-term response for patients with chronic ITP, and platelet counts on POM 3 could be used as a predictor of long-term hematological outcome.

Citing Articles

Predictive Factors for Success of Laparoscopic Splenectomy for ITP.

Nyilas A, Paszt A, Borda B, Simonka Z, Abraham S, Bereczki A JSLS. 2018; 22(4).

PMID: 30524182 PMC: 6248273. DOI: 10.4293/JSLS.2018.00021.

Platelet count on preoperative day 1 predicts the long-term responses to laparoscopic splenectomy for Chinese patients with medically refractory idiopathic thrombocytopenic purpura.

Liao R, Tang P, Song J, Qin K, Wang X, Yan X BMC Surg. 2018; 18(1):108.

PMID: 30477462 PMC: 6260580. DOI: 10.1186/s12893-018-0446-8.

Laparoscopic splenectomy for immune thrombocytopenia (ITP): long-term outcomes of a modern cohort.

Tastaldi L, Krpata D, Prabhu A, Petro C, Haskins I, Perez A Surg Endosc. 2018; 33(2):475-485.

PMID: 29987573 DOI: 10.1007/s00464-018-6321-y.

Splenectomy for immune thrombocytopenia: down but not out.

Chaturvedi S, Arnold D, McCrae K Blood. 2018; 131(11):1172-1182.

PMID: 29295846 PMC: 5855018. DOI: 10.1182/blood-2017-09-742353.

Platelet count evolution as a predictor of outcome after splenectomy for immune thrombocytopenic purpura.

Kim M, Park K, Shin W, Choe Y, Lee K, Ahn S Int J Hematol. 2016; 105(4):433-439.

PMID: 27787747 DOI: 10.1007/s12185-016-2121-0.

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