Current Opinions on Autophagy in Pathogenicity of Fungi

Overview

Journal Virulence

Specialty Microbiology

Date 2018 Nov 27

PMID 30475080

Citations 53

Authors

Xue-Ming Zhu

Lin Li

Min Wu

Shuang Liang

Huan-Bin Shi

Xiao-Hong Liu

Fu-Cheng Lin

Affiliations

Soon will be listed here.

Abstract

The interaction between pathogens and their host plants is a ubiquitous process. Some plant fungal pathogens can form a specific infection structure, such as an appressorium, which is formed by the accumulation of a large amount of glycerin and thereby the creation of an extremely high intracellular turgor pressure, which allows the penetration peg of the appressorium to puncture the leaf cuticle of the host. Previous studies have shown that autophagy energizes the accumulation of pressure by appressoria, which induces its pathogenesis. Similar to other eukaryotic organisms, autophagy processes are highly conserved pathways that play important roles in filamentous fungal pathogenicity. This review aims to demonstrate how the autophagy process affects the pathogenicity of plant pathogens.

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References

Voigt O, Poggeler S . Self-eating to grow and kill: autophagy in filamentous ascomycetes. Appl Microbiol Biotechnol. 2013; 97(21):9277-90. DOI: 10.1007/s00253-013-5221-2. View

Ruck A, Attonito J, Garces K, Nunez L, Palmisano N, Rubel Z . The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans. Autophagy. 2010; 7(4):386-400. PMC: 3108013. DOI: 10.4161/auto.7.4.14391. View

Jiang C, Zhang X, Liu H, Xu J . Mitogen-activated protein kinase signaling in plant pathogenic fungi. PLoS Pathog. 2018; 14(3):e1006875. PMC: 5854419. DOI: 10.1371/journal.ppat.1006875. View

Kikuma T, Kitamoto K . Analysis of autophagy in Aspergillus oryzae by disruption of Aoatg13, Aoatg4, and Aoatg15 genes. FEMS Microbiol Lett. 2011; 316(1):61-9. DOI: 10.1111/j.1574-6968.2010.02192.x. View

Li G, Zhou X, Xu J . Genetic control of infection-related development in Magnaporthe oryzae. Curr Opin Microbiol. 2012; 15(6):678-84. DOI: 10.1016/j.mib.2012.09.004. View

Chen L, Zhang X, Wang W, Geng X, Shi Y, Na R . Network and role analysis of autophagy in Phytophthora sojae. Sci Rep. 2017; 7(1):1879. PMC: 5431975. DOI: 10.1038/s41598-017-01988-7. View

Kim J, Huang W, Klionsky D . Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex. J Cell Biol. 2001; 152(1):51-64. PMC: 2193654. DOI: 10.1083/jcb.152.1.51. View

Ren W, Zhang Z, Shao W, Yang Y, Zhou M, Chen C . The autophagy-related gene BcATG1 is involved in fungal development and pathogenesis in Botrytis cinerea. Mol Plant Pathol. 2016; 18(2):238-248. PMC: 6638273. DOI: 10.1111/mpp.12396. View

Werner A, Herzog B, Frey S, Poggeler S . Autophagy-Associated Protein SmATG12 Is Required for Fruiting-Body Formation in the Filamentous Ascomycete Sordaria macrospora. PLoS One. 2016; 11(6):e0157960. PMC: 4911038. DOI: 10.1371/journal.pone.0157960. View

10.

Yang C, Dang X, Zheng H, Chen X, Lin X, Zhang D . Two Rab5 Homologs Are Essential for the Development and Pathogenicity of the Rice Blast Fungus . Front Plant Sci. 2017; 8:620. PMC: 5418346. DOI: 10.3389/fpls.2017.00620. View

11.

Lv W, Wang C, Yang N, Que Y, Talbot N, Wang Z . Genome-wide functional analysis reveals that autophagy is necessary for growth, sporulation, deoxynivalenol production and virulence in Fusarium graminearum. Sci Rep. 2017; 7(1):11062. PMC: 5594004. DOI: 10.1038/s41598-017-11640-z. View

12.

Zhong K, Li X, Le X, Kong X, Zhang H, Zheng X . MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 Is Important for Development of Functional Appressorium in Magnaporthe oryzae. PLoS Pathog. 2016; 12(8):e1005823. PMC: 4996533. DOI: 10.1371/journal.ppat.1005823. View

13.

Kershaw M, Talbot N . Genome-wide functional analysis reveals that infection-associated fungal autophagy is necessary for rice blast disease. Proc Natl Acad Sci U S A. 2009; 106(37):15967-72. PMC: 2747227. DOI: 10.1073/pnas.0901477106. View

14.

Deng Y, Qu Z, He Y, Naqvi N . Sorting nexin Snx41 is essential for conidiation and mediates glutathione-based antioxidant defense during invasive growth in Magnaporthe oryzae. Autophagy. 2012; 8(7):1058-70. PMC: 3429543. DOI: 10.4161/auto.20217. View

15.

Li Y, Li B, Liu L, Chen H, Zhang H, Zheng X . FgMon1, a guanine nucleotide exchange factor of FgRab7, is important for vacuole fusion, autophagy and plant infection in Fusarium graminearum. Sci Rep. 2015; 5:18101. PMC: 4674805. DOI: 10.1038/srep18101. View

16.

Noda N, Fujioka Y . Atg1 family kinases in autophagy initiation. Cell Mol Life Sci. 2015; 72(16):3083-96. PMC: 4506457. DOI: 10.1007/s00018-015-1917-z. View

17.

Zhang X, Wang G, Yang C, Huang J, Chen X, Zhou J . A HOPS Protein, MoVps41, Is Crucially Important for Vacuolar Morphogenesis, Vegetative Growth, Reproduction and Virulence in . Front Plant Sci. 2017; 8:1091. PMC: 5492488. DOI: 10.3389/fpls.2017.01091. View

18.

Voigt O, Herzog B, Jakobshagen A, Poggeler S . Autophagic kinases SmVPS34 and SmVPS15 are required for viability in the filamentous ascomycete Sordaria macrospora. Microbiol Res. 2013; 169(2-3):128-38. DOI: 10.1016/j.micres.2013.07.012. View

19.

Liu X, Xu F, Snyder J, Shi H, Lu J, Lin F . Autophagy in plant pathogenic fungi. Semin Cell Dev Biol. 2016; 57:128-137. DOI: 10.1016/j.semcdb.2016.03.022. View

20.

Zheng W, Zhou J, He Y, Xie Q, Chen A, Zheng H . Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus. PLoS Genet. 2015; 11(12):e1005704. PMC: 4686016. DOI: 10.1371/journal.pgen.1005704. View