The Role of Galectins in the Regulation of Autophagy and Inflammasome in Host Immunity

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2024 Jul 23

PMID 39042263

Authors

Tzu-Han Lo

I-Chun Weng

Hung-Lin Chen

Fu-Tong Liu

Affiliations

Soon will be listed here.

Abstract

Galectins, a family of glycan-binding proteins have been shown to bind a wide range of glycans. In the cytoplasm, these glycans can be endogenous (or "self"), originating from damaged endocytic vesicles, or exogenous (or "non-self"), found on the surface of invading microbial pathogens. Galectins can detect these unusual cytosolic exposures to glycans and serve as critical regulators in orchestrating immune responses in innate and adaptive immunity. This review provides an overview of how galectins modulate host cellular responses, such as autophagy, xenophagy, and inflammasome-dependent cell death program, to infection.

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PMID: 39544928 PMC: 11560454. DOI: 10.3389/fimmu.2024.1460023.

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