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The Long Noncoding RNA LINC00312 Induces Lung Adenocarcinoma Migration and Vasculogenic Mimicry Through Directly Binding YBX1

Overview
Journal Mol Cancer
Publisher Biomed Central
Specialties Molecular Biology
Oncology
Date 2018 Nov 25
PMID 30470227
Citations 78
Authors
Zhenzi Peng
Jun Wang
Bin Shan
Bin Li
Wei Peng
Yeping Dong
Wenwen Shi
Wenyuan Zhao
Dan He
Minghao Duan
Yuanda Cheng
Chunfang Zhang
Chaojun Duan
Affiliations
Soon will be listed here.
Abstract

Vasculogenic mimicry (VM) gives rise to tumor neovascularization that is critical for tumor growth and metastasis. Long non-coding RNAs (lncRNAs) have been implicated in diverse and fundamental biological processes. LINC00312 is associated with lung adenocarcinoma. In this study, we found that LINC00312 induced migration, invasion and VM of lung cancer cells by direct binding to the transcription factor Y-Box Binding Protein 1 (YBX1). Moreover, we demonstrated that YBX1 is associated with different fragments within 0-2410 nt 5'region of LINC00312. In addition, LINC00312 is associated with VM in 124 lung adenocarcinoma clinical specimens. The results suggest that LINC00312 is a promising therapeutic and diagnostic target for lung adenocarcinoma.

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References
1.
Lasham A, Print C, Woolley A, Dunn S, Braithwaite A . YB-1: oncoprotein, prognostic marker and therapeutic target?. Biochem J. 2012; 449(1):11-23. DOI: 10.1042/BJ20121323. View
2.
Smolle M, Pichler M . The Role of Long Non-Coding RNAs in Osteosarcoma. Noncoding RNA. 2018; 4(1). PMC: 5890394. DOI: 10.3390/ncrna4010007. View
3.
Sun J, Sun B, Sun R, Zhu D, Zhao X, Zhang Y . HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma. Sci Rep. 2017; 7(1):2229. PMC: 5440402. DOI: 10.1038/s41598-017-02494-6. View
4.
Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X . Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol. 2013; 44(5):545-54. DOI: 10.1007/s10735-013-9503-x. View
5.
Peng Z, Wang J, Shan B, Yuan F, Li B, Dong Y . Genome-wide analyses of long noncoding RNA expression profiles in lung adenocarcinoma. Sci Rep. 2017; 7(1):15331. PMC: 5681506. DOI: 10.1038/s41598-017-15712-y. View