Genetic Variants in LncRNA HOTAIR Are Associated with Lung Cancer Susceptibility in a Chinese Han Population in China: a Case-control Study

Overview

Journal Cancer Manag Res

Publisher Dove Medical Press

Specialty Oncology

Date 2018 Nov 23

PMID 30464618

Citations 11

Authors

Hang Li

Zitai Yang

Juan Li

Xiaoting Lv

Min Gao

Yanhong Bi

Ziwei Zhang

Shengli Wang

Sixuan Li

Na Li

Zhigang Cui

Baosen Zhou

Zhihua Yin

Affiliations

Soon will be listed here.

Abstract

Purpose: HOX transcript antisense RNA (HOTAIR) plays important roles in carcinogenesis of various kinds of malignant tumors, including lung cancer. Single nucleotide polymorphisms (SNPs) in HOTAIR were reported to be associated with susceptibility of several kinds of cancers. The present study assessed the associations between three SNPs (rs4759314, rs12826786, and rs920778) and lung cancer susceptibility, as well as gene-environment interaction between smoking exposure and the polymorphisms.

Patients And Methods: A case-control study including 551 patients and 543 healthy controls was performed. The associations between SNPs and lung cancer susceptibility were assessed by logistic regression model.

Results: rs4759314 was observed to increase the susceptibility of lung cancer, lung adenocarcinoma, squamous lung cancer, and small cell lung cancer statistically significantly (OR of 4.048 for lung cancer; 3.584 for lung adenocarcinoma; 4.671 for squamous lung cancer; 4.502 for small cell lung cancer). In stratified analysis for sex and smoking exposure, rs4759314 GG and AG genotype was also observed to increase the risk of lung cancer statistically significantly (OR of 5.221 for male; 3.491 for female; 3.653 for nonsmoking individuals; 4.458 for smoking individuals). Results of gene-environment interaction analysis showed that there was no interaction between smoking exposure and rs4759314 on additive scale. Results of logistic regression model suggested that the interaction between smoking and rs4759314 was statistically significant on multiplicative scale. rs12826786 CT genotype carriers and T allele could decrease the risk of developing lung cancer (OR of 0.751 for CT carriers; 0.785 for T allele), and in dominant model, TC and TT genotype carriers also have a 0.249-fold decrease risk compared with CC genotype carriers. In stratified analysis for smoking exposure, TC and TT have a 0.432-fold decreased risk compared with CC genotype carriers.

Conclusion: HOTAIR rs4759314 and rs12826786 were associated with lung cancer susceptibility in Chinese Han population.

Citing Articles

LncRNA gene polymorphisms and their influence on lung cancer patients in the Chinese Han population.

Wu H, Xie Y, Li A, Liu X, Guo L, Wu F Noncoding RNA Res. 2024; 10:252-260.

PMID: 39611047 PMC: 11602538. DOI: 10.1016/j.ncrna.2024.10.008.

Comprehensive investigation of long non-coding RNA HOTAIR polymorphisms and cancer risk: a current meta-analysis encompassing 96,458 participants.

Krishna B, Garg P, Ramisetty S, Subbalakshmi A, Kulkarni P, Salgia R Sci Rep. 2024; 14(1):22670.

PMID: 39349529 PMC: 11442654. DOI: 10.1038/s41598-024-72586-7.

The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: A Step toward ncRNA Precision.

Eldash S, Sanad E, Nada D, Hamdy N Noncoding RNA. 2023; 9(5).

PMID: 37888204 PMC: 10610215. DOI: 10.3390/ncrna9050058.

Association of HOTAIR rs2366152 and rs1899663 polymorphisms with colorectal cancer susceptibility in Iranian population: A case-control study.

Eivazi N, Mirfakhraie R, Nazemalhosseini Mojarad E, Behroozi J, Yassaee V, Tahmaseb M J Clin Lab Anal. 2023; 37(9-10):e24931.

PMID: 37337955 PMC: 10388228. DOI: 10.1002/jcla.24931.

Association between long non-coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta-analysis.

Ke C, Feng X, Li J, Chen S, Hu X Exp Ther Med. 2022; 24(2):540.

PMID: 35837044 PMC: 9257968. DOI: 10.3892/etm.2022.11477.

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