Genetic Mechanisms Behind the Spread of Reduced Susceptibility to Azithromycin in Strains Isolated from Men Who Have Sex with Men in Québec, Canada

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2018 Nov 21

PMID 30455248

Citations 14

Authors

Khadidja Yousfi

Christiane Gaudreau

Pierre A Pilon

Brigitte Lefebvre

Matthew Walker

Eric Fournier

Florence Doualla Bell

Christine Martineau

Jean Longtin

Sadjia Bekal

Affiliations

Soon will be listed here.

Abstract

We analyzed 254 species isolates collected in Québec, Canada, during 2013 and 2014. Overall, 23.6% of isolates showed reduced susceptibility to azithromycin (RSA) encoded by (11.6%), (1.7%), or both genes (86.7%). strains with RSA were mostly isolated from men who have sex with men (68.8% or higher) from the Montreal region. A complete sequence analysis of six selected plasmids from and different serotypes of emphasized the role of IS in the dissemination of RSA.

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