Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2018 Nov 21

PMID 30455235

Citations 5

Authors

George R Thompson 3rd

Charles R Krois

Verena K Affolter

Angela D Everett

E Katarina Varjonen

Victoria R Sharon

Anil Singapuri

Michael Dennis

Ian McHardy

Hong Sik Yoo

Dawn M Fedor

Nathan P Wiederhold

Phylicia A Aaron

Angie Gelli

Joseph L Napoli

Stephen D White

Affiliations

Soon will be listed here.

Abstract

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

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