Associations of Immunological Factors with Metabolic Syndrome and Its Characteristic Elements in Chinese Centenarians

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2018 Nov 21

PMID 30454064

Citations 15

Authors

Shihui Fu

Yao Yao

Faqin Lv

Fu Zhang

Yali Zhao

Fuxin Luan

Affiliations

Soon will be listed here.

Abstract

Background: Metabolic syndrome (MetS) has an increased prevalence (approximately 20-25% of the adult population) all over the world. Immunological function is significantly associated with the development of MetS, and MetS is beginning to be considered as a chronic immune-related disease. The present study addressed on the associations of immunological factors with MetS and its characteristic elements in Chinese centenarians.

Methods: Hainan is a longevity region with the highest population density of centenarians in China. The China Hainan Centenarian Cohort Study has a considerable sample size, and provides a significant population-based sample of centenarians. Home interview, physical examination and blood analysis were conducted following standard procedures.

Results: All centenarians had a median age of 102 (100-115) years, and the proportion of females was 80.8%. The proportion of centenarians with MetS was 16.0% (135 centenarians). Abdominal obesity, hypertension, dyslipidemia and diabetes mellitus had a prevalence of 26.4% (223 centenarians), 73.7% (623 centenarians), 40.4% (341 centenarians) and 10.7% (90 centenarians), respectively. In Logistic regression analyses, MetS was significantly associated with immunoglobulin E and complement C3 levels (P < 0.05 for all). Abdominal obesity was significantly associated with immunoglobulin E and complement C3 levels (P < 0.05 for all).

Conclusions: The present study provides epidemiological evidence that MetS has significant associations with immunoglobulin E and complement C3 levels, and demonstrates that abdominal obesity is significantly associated with immunoglobulin E and complement C3 levels in Chinese centenarians.

Citing Articles

An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging.

Melendez J, Sung Y, Orr M, Yoo A, Schindler S, Cruchaga C Aging Cell. 2024; 23(9):e14230.

PMID: 38923730 PMC: 11488306. DOI: 10.1111/acel.14230.

C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio, and Long-Term Mortality in Chinese Centenarians.

Zhu Q, Zhang Q, Chen C, Liu M, He Y, Zhao Y JAMA Netw Open. 2023; 6(10):e2340307.

PMID: 37902758 PMC: 10616724. DOI: 10.1001/jamanetworkopen.2023.40307.

Associations between lipid profiles and late-life cognitive impairment among oldest-old and centenarian adults.

Chen Y, Yang K, Huang Y, Wang X, Zhao Y, Ping P MedComm (2020). 2023; 4(5):e362.

PMID: 37692108 PMC: 10484073. DOI: 10.1002/mco2.362.

Positive associations between sex hormones, bone metabolism and cognitive impairment in Chinese oldest-old females.

Feng L, Bian L, Ning C, Zhang P, Zhao Y, Gao Z BMC Psychiatry. 2023; 23(1):562.

PMID: 37542223 PMC: 10403843. DOI: 10.1186/s12888-023-04957-9.

Feng L, Wu D, Ping P, Lin J, Zhao Y, Yao Y J Inflamm Res. 2022; 15:6675-6682.

PMID: 36532650 PMC: 9749409. DOI: 10.2147/JIR.S344105.

References

Kastorini C, Panagiotakos D, Georgousopoulou E, Laskaris A, Skourlis N, Zana A . Metabolic syndrome and 10-year cardiovascular disease incidence: The ATTICA study. Nutr Metab Cardiovasc Dis. 2016; 26(3):223-31. DOI: 10.1016/j.numecd.2015.12.010. View

Fu S, Yao Y, Luan F, Zhao Y . Prevalence of metabolic syndrome risk factors and their relationships with renal function in Chinese centenarians. Sci Rep. 2018; 8(1):9863. PMC: 6026211. DOI: 10.1038/s41598-018-28316-x. View

Chen C, Lu F . The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2005; 17 Suppl:1-36. View

Evert J, Lawler E, Bogan H, Perls T . Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci. 2003; 58(3):232-7. DOI: 10.1093/gerona/58.3.m232. View

Liu J, Divoux A, Sun J, Zhang J, Clement K, Glickman J . Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009; 15(8):940-5. PMC: 2736875. DOI: 10.1038/nm.1994. View

Fouejeu Wamba P, Mi J, Zhao X, Zhang M, Wen Y, Cheng H . Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents. Eur J Endocrinol. 2008; 159(6):781-90. DOI: 10.1530/EJE-08-0467. View

Ford E, Giles W, Dietz W . Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002; 287(3):356-9. DOI: 10.1001/jama.287.3.356. View

Karkhaneh M, Qorbani M, Mohajeri-Tehrani M, Hoseini S . Association of serum complement C3 with metabolic syndrome components in normal weight obese women. J Diabetes Metab Disord. 2018; 16:49. PMC: 5745599. DOI: 10.1186/s40200-017-0330-6. View

Germinario R, Sniderman A, Manuel S, Lefebvre S, Baldo A, Cianflone K . Coordinate regulation of triacylglycerol synthesis and glucose transport by acylation-stimulating protein. Metabolism. 1993; 42(5):574-80. DOI: 10.1016/0026-0495(93)90215-a. View

10.

Gabrielsson B, Johansson J, Lonn M, Jernas M, Olbers T, Peltonen M . High expression of complement components in omental adipose tissue in obese men. Obes Res. 2003; 11(6):699-708. DOI: 10.1038/oby.2003.100. View

11.

Muscari A, Bastagli L, Poggiopollini G, Tomassetti V, Massarelli G, Cappelletti O . Different associations of C-reactive protein, fibrinogen and C3 with traditional risk factors in middle-aged men. Int J Cardiol. 2002; 83(1):63-71. DOI: 10.1016/s0167-5273(02)00017-7. View

12.

. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2001; 894:i-xii, 1-253. View

13.

Hotamisligil G . Inflammation and metabolic disorders. Nature. 2006; 444(7121):860-7. DOI: 10.1038/nature05485. View

14.

Eckel R, Alberti K, Grundy S, Zimmet P . The metabolic syndrome. Lancet. 2010; 375(9710):181-3. DOI: 10.1016/S0140-6736(09)61794-3. View

15.

Alberti K, Zimmet P, Shaw J . The metabolic syndrome--a new worldwide definition. Lancet. 2005; 366(9491):1059-62. DOI: 10.1016/S0140-6736(05)67402-8. View

16.

Wang J, Cheng X, Xiang M, Alanne-Kinnunen M, Wang J, Chen H . IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011; 121(9):3564-77. PMC: 3163955. DOI: 10.1172/JCI46028. View

17.

Warnberg J, Marcos A . Low-grade inflammation and the metabolic syndrome in children and adolescents. Curr Opin Lipidol. 2008; 19(1):11-5. DOI: 10.1097/MOL.0b013e3282f4096b. View

18.

de Carvalho Vidigal F, Ribeiro A, Babio N, Salas-Salvado J, Bressan J . Prevalence of metabolic syndrome and pre-metabolic syndrome in health professionals: LATINMETS Brazil study. Diabetol Metab Syndr. 2015; 7:6. PMC: 4339435. DOI: 10.1186/s13098-015-0003-x. View

19.

Muscari A, Massarelli G, Bastagli L, Poggiopollini G, Tomassetti V, Drago G . Relationship of serum C3 to fasting insulin, risk factors and previous ischaemic events in middle-aged men. Eur Heart J. 2000; 21(13):1081-90. DOI: 10.1053/euhj.1999.2013. View

20.

Puchau B, Zulet M, Gonzalez de Echavarri A, Navarro-Blasco I, Martinez J . Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults. Eur J Clin Nutr. 2008; 63(7):858-64. DOI: 10.1038/ejcn.2008.48. View