Ultrasonic Based Tissue Modelling and Engineering

Overview

Journal Micromachines (Basel)

Publisher MDPI

Date 2018 Nov 17

PMID 30441752

Citations 14

Authors

Karl Olofsson

Bjorn Hammarstrom

Martin Wiklund

Affiliations

Soon will be listed here.

Abstract

Systems and devices for in vitro tissue modelling and engineering are valuable tools, which combine the strength between the controlled laboratory environment and the complex tissue organization and environment in vivo. Device-based tissue engineering is also a possible avenue for future explant culture in regenerative medicine. The most fundamental requirements on platforms intended for tissue modelling and engineering are their ability to shape and maintain cell aggregates over long-term culture. An emerging technology for tissue shaping and culture is ultrasonic standing wave (USW) particle manipulation, which offers label-free and gentle positioning and aggregation of cells. The pressure nodes defined by the USW, where cells are trapped in most cases, are stable over time and can be both static and dynamic depending on actuation schemes. In this review article, we highlight the potential of USW cell manipulation as a tool for tissue modelling and engineering.

Citing Articles

Wave-momentum shaping for moving objects in heterogeneous and dynamic media.

Orazbayev B, Mallejac M, Bachelard N, Rotter S, Fleury R Nat Phys. 2024; 20(9):1441-1447.

PMID: 39282552 PMC: 11392811. DOI: 10.1038/s41567-024-02538-5.

Improved functionality of hepatic spheroids cultured in acoustic levitation compared to existing 2D and 3D models.

Rabiet L, Jeger-Madiot N, Garcia D, Tosca L, Tachdjian G, Kellouche S Sci Rep. 2024; 14(1):21528.

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Acoustic Actuators for the Manipulation of Micro/Nanorobots: State-of-the-Art and Future Outlooks.

Cao H, Nguyen V, Park J, Choi E, Kang B Micromachines (Basel). 2024; 15(2).

PMID: 38398914 PMC: 10890471. DOI: 10.3390/mi15020186.

Acoustofluidic Interfaces for the Mechanobiological Secretome of MSCs.

He Y, Yang S, Liu P, Li K, Jin K, Becker R Nat Commun. 2023; 14(1):7639.

PMID: 37993431 PMC: 10665559. DOI: 10.1038/s41467-023-43239-6.

Acoustic and Magnetic Stimuli-Based Three-Dimensional Cell Culture Platform for Tissue Engineering.

Seo J, Park S, Kim S, Seo G, Jang H, Lee T Tissue Eng Regen Med. 2023; 20(4):563-580.

PMID: 37052782 PMC: 10313605. DOI: 10.1007/s13770-023-00539-8.

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