Treatment and Prevention of Pertussis by Antimicrobial Agents (Part II)

Overview

Journal Infection

Date 1988 May 1

PMID 3042626

Citations 13

Authors

J E Hoppe

A Haug

Affiliations

Soon will be listed here.

Abstract

Suitable antimicrobials given during the catarrhal stage of whooping cough can attenuate the course of the disease. The efficacy of antibiotics administered prophylactically during the incubation period remains controversial but appears to be beneficial. Currently, erythromycin given for two weeks is the antibiotic of choice for pertussis. No treatment failures were observed with erythromycin estolate. Erythromycin ethylsuccinate and stearate must be given at high dosages (50-60 mg/kg/day) in order to achieve sufficient concentrations in the respiratory secretions. With ampicillin and amoxicillin treatment failures have been observed. The role of josamycin and co-trimoxazole in pertussis remains open.

Citing Articles

High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014-2016.

Li L, Deng J, Ma X, Zhou K, Meng Q, Yuan L Emerg Infect Dis. 2019; 25(12):2205-2214.

PMID: 31742507 PMC: 6874251. DOI: 10.3201/eid2512.181836.

[Antimicrobial susceptibility and antigen genotypes of Bordetella pertussis strains isolated from neonates].

Li L, Liu Y, Jia J, Yuan L, Shi W, Meng Q Zhongguo Dang Dai Er Ke Za Zhi. 2019; 21(3):208-213.

PMID: 30907341 PMC: 7389359.

[Prevalence of Bordetella pertussis infection in children with chronic cough and its clinical features].

Wu D, Chen Q, Li L, Shen K, Yao K Zhongguo Dang Dai Er Ke Za Zhi. 2019; 21(1):18-23.

PMID: 30675858 PMC: 7390172.

Pertussis: Microbiology, Disease, Treatment, and Prevention.

Kilgore P, Salim A, Zervos M, Schmitt H Clin Microbiol Rev. 2016; 29(3):449-86.

PMID: 27029594 PMC: 4861987. DOI: 10.1128/CMR.00083-15.

Antibiotics for whooping cough (pertussis).

Altunaiji S, Kukuruzovic R, Curtis N, Massie J Cochrane Database Syst Rev. 2007; (3):CD004404.

PMID: 17636756 PMC: 11322855. DOI: 10.1002/14651858.CD004404.pub3.

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