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Effect of Erythromycin and Amoxycillin on Bordetella Pertussis in the Nasopharynx

Overview
Journal Infection
Date 1978 Jan 1
PMID 215555
Citations 9
Authors
B Trollfors
Affiliations
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Abstract

The effectiveness of oral erythromycin and amoxycillin in eradicating Bordetella pertussis from the nasopharynx was compared. Erythromycin in a dosage of 40--50 mg/kg/day was significantly more effective than amoxycillin in a dosage of 25--30 mg/kg/day. The organism did not disappear in three cases receiving a lower dosage of erythromycin. As antibiotic treatment does not affect the clinical course of fully-developed whooping cough, erythromycin is indicated primarily when particularly susceptible individuals are threatened by exposure. In such cases erythromycin should be given as soon as whooping cough is suspected.

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[Antimicrobial susceptibility and antigen genotypes of Bordetella pertussis strains isolated from neonates].

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Pertussis: Microbiology, Disease, Treatment, and Prevention.

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Antibiotics for whooping cough (pertussis).

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