Viscodilation of Schlemm's Canal for the Reduction of IOP Via an Ab-interno Approach

Overview

Journal Clin Ophthalmol

Publisher Dove Medical Press

Specialty Ophthalmology

Date 2018 Nov 15

PMID 30425450

Citations 30

Authors

Mark J Gallardo

Richard A Supnet

Iqbal Ike K Ahmed

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to compare the 1-year efficacy and safety profile of ab-interno canaloplasty (ABiC) when performed as a stand-alone procedure or as an adjunct to cataract extraction in reducing IOP and glaucoma medication dependence.

Patients And Methods: This retrospective, comparative, consecutive case series included patients with uncontrolled primary open-angle glaucoma (POAG) who underwent ABiC as a stand-alone procedure or in conjunction with cataract extraction. Data were collected over a 12-month period. Primary outcome measures were mean lower IOP and mean number of glaucoma medications. Secondary endpoints included surgical and postsurgical complications and secondary interventions.

Results: The study included 75 eyes of 68 patients (mean age: 73.7±9.9 years) with a mean baseline IOP of 20.4±4.7 mmHg on 2.8±0.9 medications, which reduced to 13.3±1.9 mmHg (n=73) on 1.1±1.1 medications at 12 months postoperative (both <0.0001). At 12 months, 40% of eyes were medication free. In the ABiC/phacoemulsification subgroup (n=34 eyes), the mean IOP and medication use decreased from 19.4±3.7 mmHg on 2.6±1.0 medications preoperatively to 13.0±1.8 mmHg on 0.8±0.2 medications at 12 months (both <0.001). In the stand-alone ABiC subgroup (n=41), the mean IOP and medication use decreased from 21.2±5.3 mmHg on 3.0±0.7 medications preoperatively to 13.7±1.9 mmHg on 1.3±1.1 medications at 12 months (=0.001 and <0.001, respectively). No serious adverse events were recorded.

Conclusion: These data demonstrate that ABiC was effective at reducing IOP and medication use in eyes with uncontrolled POAG with or without cataract surgery.

Citing Articles

Ab externo Schlemm's canal surgery: Efficacy and safety outcomes.

Batailde G, Ginderachter A, Eijgen J, Sunaric-Megevand G, Stalmans I, Lemmens S Saudi J Ophthalmol. 2025; 38(4):322-331.

PMID: 39943953 PMC: 11811411. DOI: 10.4103/sjopt.sjopt_159_24.

Safety and Efficacy of STREAMLINE Canaloplasty with Phacoemulsification in Hispanic Adults with Open-Angle Glaucoma: 12-Month Outcomes.

Lazcano-Gomez G, Orlich C, Batlle J, Ison E, Reynolds H, Harbin M Clin Ophthalmol. 2025; 18:3967-3976.

PMID: 39741793 PMC: 11687135. DOI: 10.2147/OPTH.S473981.

Evaluating the 1-year success and safety of ab interno canaloplasty in combination with cataract surgery in glaucoma patients.

Nassri L, Prinz J, Schellhase H, Fuest M, Koutsonas A, Plange N Int Ophthalmol. 2024; 44(1):406.

PMID: 39400779 PMC: 11473546. DOI: 10.1007/s10792-024-03325-0.

A Review of Canaloplasty in the Treatment and Management of Glaucoma.

Wagner I, Towne C, Saade M, Lentz P, Rashedi A, Vasu P J Curr Glaucoma Pract. 2024; 18(2):79-85.

PMID: 39144728 PMC: 11320757. DOI: 10.5005/jp-journals-10078-1442.

Long-term outcomes of canaloplasty and phaco-canaloplasty in the treatment of open angle glaucoma: a single-surgeon experience.

Tognetto D, Cirigliano G, Gouigoux S, Grotto A, Guerin P, Inferrera L Int Ophthalmol. 2024; 44(1):317.

PMID: 38972018 PMC: 11228002. DOI: 10.1007/s10792-024-03174-x.

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