Three-year Canaloplasty Outcomes for the Treatment of Open-angle Glaucoma: European Study Results

Overview

Journal Graefes Arch Clin Exp Ophthalmol

Specialty Ophthalmology

Date 2011 Jul 7

PMID 21732110

Citations 67

Authors

Holger Bull

Kurt von Wolff

Norbert Korber

Manfred Tetz

Affiliations

Soon will be listed here.

Abstract

Background: To report 3-year results investigating the safety and efficacy of canaloplasty, a procedure involving circumferential viscodilation of Schlemm's canal and tensioning of the inner canal wall to treat open-angle glaucoma.

Methods: This was a prospective, multi-center, interventional study of 109 eyes of 109 adult, open-angle glaucoma patients undergoing canaloplasty or combined cataract-canaloplasty surgery. Qualifying preoperative intraocular pressures (IOP) were at least 16 mmHg with historical IOPs of at least 21 mmHg with or without medical therapy. A flexible microcatheter was used to viscodilate the full circumference of the canal and to place a trabecular tensioning suture. Primary outcome measures included IOP, glaucoma medication usage, and adverse events.

Results: Eyes with canaloplasty showed a mean baseline IOP of 23.0 ± 4.3 mmHg and mean glaucoma medication usage of 1.9 ± 0.7 medications, which decreased to a mean IOP of 15.1 ± 3.1 mmHg on 0.9 ± 0.9 medications at 3 years postoperatively. Eyes with combined cataract-canaloplasty surgery showed a mean baseline IOP of 24.3 ± 6.0 mmHg on 1.5 ± 1.2 medications, which decreased to a mean IOP of 13.8 ± 3.2 mmHg on 0.5 ± 0.7 medications at 3 years. Intraocular pressure and medication use results for all study eyes were significantly decreased from baseline (p <0.00001) at all intervals. Late postoperative complications included cataracts (19.1%) and transient IOP elevation (1.8%).

Conclusions: Canaloplasty demonstrated significant and sustained IOP reductions accompanied by an excellent short- and long-term safety profile in adult patients with open-angle glaucoma.

Citing Articles

Long-term efficacy and safety of ab externo canaloplasty in the Polish Caucasian population with open-angle glaucoma: A 3-year retrospective study.

Konopinska J, Golaszewska K, Saeed E PLoS One. 2024; 19(10):e0312236.

PMID: 39413111 PMC: 11482709. DOI: 10.1371/journal.pone.0312236.

Historical and Contemporary Debates in Schlemm's Canal-Based MIGS.

Chihara E, Hamanaka T J Clin Med. 2024; 13(16).

PMID: 39201024 PMC: 11355781. DOI: 10.3390/jcm13164882.

A Review of Canaloplasty in the Treatment and Management of Glaucoma.

Wagner I, Towne C, Saade M, Lentz P, Rashedi A, Vasu P J Curr Glaucoma Pract. 2024; 18(2):79-85.

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Long-term outcomes of canaloplasty and phaco-canaloplasty in the treatment of open angle glaucoma: a single-surgeon experience.

Tognetto D, Cirigliano G, Gouigoux S, Grotto A, Guerin P, Inferrera L Int Ophthalmol. 2024; 44(1):317.

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New suture probe canaloplasty combined with suprachoroidal collagen implantation.

Haus A, Szurman P, Muller L, Farese G, Seuthe A Int Ophthalmol. 2024; 44(1):208.

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