Immunotoxicological Evaluation of L. (Anacardiaceae) Essential Oil in Lymphocytes and Macrophages

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2018 Nov 10

PMID 30410557

Citations 3

Authors

Jonathaline Apollo Duarte

Lea Augusta de Bairros Zambrano

Luciane Dias Quintana

Mariana Balhego Rocha

Elizandra Gomes Schmitt

Aline Augusti Boligon

Marli Matiko Anraku de Campos

Luis Flavio Souza de Oliveira

Michel Mansur Machado

Affiliations

Soon will be listed here.

Abstract

L. is used to treat various diseases; however, the literature lacks information regarding its possible immunotoxic effects. The aim of the study was to investigate the immunotoxic effects of essential oil from leaves of . in cultures of human lymphocytes and macrophages. The cultures were treated with essential oil (EO) of L. and subsequently subjected to genotoxic analysis (comet assay), mutagenic analysis (micronucleus frequency and chromosomal aberration), and cytotoxic (cell viability) and functional parameters (interleukins secretions). Our analyses have determined that the essential oil from leaves of L. presents several compounds with -pinene being the major compound; in addition, the compound verbenene was firstly identified; genotoxic effects were detected only in macrophages and only at the two highest concentrations tested. An important finding is that L. oil causes an activation of the immune system. This action has its mechanism centered by the cascade nitric oxide-interleukin-10-tumor necrosis factor alpha.

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