Immunotoxicology: A Brief History, Current Status and Strategies for Future Immunotoxicity Assessment

Overview

Journal Curr Opin Toxicol

Date 2017 Oct 10

PMID 28989989

Citations 10

Authors

Dori Germolec

Robert Luebke

Andrew Rooney

Kelly Shipkowski

Rob Vandebriel

Henk Van Loveren

Affiliations

Soon will be listed here.

Citing Articles

Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms.

Daood N, Russo D, Chung E, Qin X, Zhu H Environ Health (Wash). 2024; 2(7):474-485.

PMID: 39049897 PMC: 11264268. DOI: 10.1021/envhealth.4c00026.

Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures.

Bulka C, Enggasser A, Fry R Curr Environ Health Rep. 2022; 9(3):477-489.

PMID: 35648356 PMC: 9157479. DOI: 10.1007/s40572-022-00353-9.

Rotenone Modulates Immunometabolism and Pathogen Susceptibility.

Mello D, Bergemann C, Fisher K, Chitrakar R, Bijwadia S, Wang Y Front Immunol. 2022; 13:840272.

PMID: 35273616 PMC: 8902048. DOI: 10.3389/fimmu.2022.840272.

Can Environmental Pollutants Be a Factor Linking Obesity and COVID-19?.

Lee D J Korean Med Sci. 2021; 36(43):e305.

PMID: 34751012 PMC: 8575764. DOI: 10.3346/jkms.2021.36.e305.

Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation.

Halamoda-Kenzaoui B, Vandebriel R, Howarth A, Siccardi M, David C, Liptrott N J Control Release. 2021; 336:192-206.

PMID: 34126169 PMC: 8390938. DOI: 10.1016/j.jconrel.2021.06.016.

References

Dean J, Luster M, Boorman G, Lauer L . Procedures available to examine the immunotoxicity of chemicals and drugs. Pharmacol Rev. 1982; 34(1):137-48. View

Granum B, Haug L, Namork E, Stolevik S, Thomsen C, Aaberge I . Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. J Immunotoxicol. 2013; 10(4):373-9. DOI: 10.3109/1547691X.2012.755580. View

Kimura Y, Fujimura C, Ito Y, Takahashi T, Aiba S . Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs. Toxicol In Vitro. 2014; 28(5):759-68. DOI: 10.1016/j.tiv.2014.02.013. View

Lankveld D, van Loveren H, Baken K, Vandebriel R . In vitro testing for direct immunotoxicity: state of the art. Methods Mol Biol. 2009; 598:401-23. DOI: 10.1007/978-1-60761-401-2_26. View

Hochstenbach K, van Leeuwen D, Gmuender H, Gottschalk R, Stolevik S, Nygaard U . Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns. Toxicol Sci. 2012; 129(2):315-24. PMC: 3529642. DOI: 10.1093/toxsci/kfs214. View

Day D, Hansen A . Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitors. BioDrugs. 2016; 30(6):571-584. DOI: 10.1007/s40259-016-0204-3. View

Kleinstreuer N, Sullivan K, Allen D, Edwards S, Mendrick D, Embry M . Adverse outcome pathways: From research to regulation scientific workshop report. Regul Toxicol Pharmacol. 2016; 76:39-50. PMC: 11027510. DOI: 10.1016/j.yrtph.2016.01.007. View

Pennings J, Jennen D, Nygaard U, Namork E, Haug L, Van Loveren H . Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood. J Immunotoxicol. 2015; 13(2):173-80. DOI: 10.3109/1547691X.2015.1029147. View

Stolevik S, Nygaard U, Namork E, Haugen M, Kvalem H, Meltzer H . Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. Food Chem Toxicol. 2011; 49(8):1843-8. DOI: 10.1016/j.fct.2011.05.002. View

10.

Luster M, Portier C, Pait D, White Jr K, Gennings C, MUNSON A . Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam Appl Toxicol. 1992; 18(2):200-10. DOI: 10.1016/0272-0590(92)90047-l. View

11.

Kleinstreuer N, Yang J, Berg E, Knudsen T, Richard A, Martin M . Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms. Nat Biotechnol. 2014; 32(6):583-91. DOI: 10.1038/nbt.2914. View

12.

Luebke R, Parks C, Luster M . Suppression of immune function and susceptibility to infections in humans: association of immune function with clinical disease. J Immunotoxicol. 2008; 1(1):15-24. DOI: 10.1080/15476910490438342. View

13.

Exon J, Bussiere J, Mather G . Immunotoxicity testing in the rat: an improved multiple assay model. Int J Immunopharmacol. 1990; 12(6):699-701. DOI: 10.1016/0192-0561(90)90108-y. View

14.

Rovida C, Alepee N, Api A, Basketter D, Bois F, Caloni F . Integrated Testing Strategies (ITS) for safety assessment. ALTEX. 2014; 32(1):25-40. DOI: 10.14573/altex.1411011. View

15.

Vandebriel R, Pennings J, Baken K, Pronk T, Boorsma A, Gottschalk R . Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010; 117(1):81-9. DOI: 10.1093/toxsci/kfq182. View

16.

Dean J, Padarathsingh M, Jerrells T . Assessment of immunobiological effects induced by chemicals, drugs or food additives. I. Tier testing and screening approach. Drug Chem Toxicol. 1979; 2(1-2):5-17. DOI: 10.3109/01480547908993178. View

17.

Luster M, Portier C, Pait D, Rosenthal G, Germolec D, Corsini E . Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests. Fundam Appl Toxicol. 1993; 21(1):71-82. DOI: 10.1006/faat.1993.1074. View

18.

Keil D, Luebke R, Pruett S . Quantifying the relationship between multiple immunological parameters and host resistance: probing the limits of reductionism. J Immunol. 2001; 167(8):4543-52. DOI: 10.4049/jimmunol.167.8.4543. View

19.

Zang Q, Paris M, Lehmann D, Bell S, Kleinstreuer N, Allen D . Prediction of skin sensitization potency using machine learning approaches. J Appl Toxicol. 2017; 37(7):792-805. PMC: 5435511. DOI: 10.1002/jat.3424. View

20.

Strickland J, Zang Q, Paris M, Lehmann D, Allen D, Choksi N . Multivariate models for prediction of human skin sensitization hazard. J Appl Toxicol. 2016; 37(3):347-360. PMC: 5243794. DOI: 10.1002/jat.3366. View