The Common Truncation Variant in Pancreatic Lipase Related Protein 2 (PNLIPRP2) is Expressed Poorly and Does Not Alter Risk for Chronic Pancreatitis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Nov 9

PMID 30408063

Citations 6

Authors

Balazs Csaba Nemeth

Zsofia Gabriella Pesei

Eszter Hegyi

Akos Szucs

Andrea Szentesi

Peter Hegyi

Mark E Lowe

Miklos Sahin-Toth

Affiliations

Soon will be listed here.

Abstract

A nonsense variant (p.W358X) of human pancreatic lipase related protein 2 (PNLIPRP2) is present in different ethnic populations with a high allele frequency. In cell culture experiments, the truncated protein mainly accumulates inside the cells and causes endoplasmic reticulum stress. Here, we tested the hypothesis that variant p.W358X might increase risk for chronic pancreatitis through acinar cell stress. We sequenced exon 11 of PNLIPRP2 in a cohort of 256 subjects with chronic pancreatitis (152 alcoholic and 104 non-alcoholic) and 200 controls of Hungarian origin. We observed no significant difference in the distribution of the truncation variant between patients and controls. We analyzed mRNA expression in human pancreatic cDNA samples and found the variant allele markedly reduced. We conclude that the p.W358X truncation variant of PNLIPRP2 is expressed poorly and has no significant effect on the risk of chronic pancreatitis.

Citing Articles

The 12-Year Experience of the Hungarian Pancreatic Study Group.

Szentesi A, Hegyi P, The Hungarian Pancreatic Study Group J Clin Med. 2025; 14(4).

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Characterization of novel PNLIP variants in congenital pancreatic lipase deficiency.

Lin J, Matiwala N, Curry G, Wilhelm S, Cassidy B, Lowe M Pancreatology. 2023; 23(8):1036-1040.

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Zhong W, Edfors F, Gummesson A, Bergstrom G, Fagerberg L, Uhlen M Nat Commun. 2021; 12(1):2493.

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Xia C, Zhang X, Cao T, Wang J, Li C, Yue L Front Endocrinol (Lausanne). 2020; 11:565858.

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