A Systematic Knowledge Synthesis on the Spatial Dimensions of Q Fever Epidemics

Overview

Journal Zoonoses Public Health

Specialties Public Health
Veterinary Medicine

Date 2018 Nov 8

PMID 30402920

Citations 5

Authors

Myrna M T de Rooij

Jeroen P G van Leuken

Arno Swart

Mirjam E E Kretzschmar

Mirjam Nielen

Aline A de Koeijer

Ingmar Janse

Inge M Wouters

Dick J J Heederik

Affiliations

Soon will be listed here.

Abstract

From 2007 through 2010, the Netherlands experienced the largest Q fever epidemic ever reported. This study integrates the outcomes of a multidisciplinary research programme on spatial airborne transmission of Coxiella burnetii and reflects these outcomes in relation to other scientific Q fever studies worldwide. We have identified lessons learned and remaining knowledge gaps. This synthesis was structured according to the four steps of quantitative microbial risk assessment (QMRA): (a) Rapid source identification was improved by newly developed techniques using mathematical disease modelling; (b) source characterization efforts improved knowledge but did not provide accurate C. burnetii emission patterns; (c) ambient air sampling, dispersion and spatial modelling promoted exposure assessment; and (d) risk characterization was enabled by applying refined dose-response analyses. The results may support proper and timely risk assessment and risk management during future outbreaks, provided that accurate and structured data are available and exchanged readily between responsible actors.

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A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics.

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