Energy Restriction in Renal Protection

Overview

Journal Br J Nutr

Specialty Nutritional Sciences

Date 2018 Nov 8

PMID 30401006

Citations 17

Authors

Si-Yang Wang

Guang-Yan Cai

Xiang-Mei Chen

Affiliations

Soon will be listed here.

Abstract

Energy restriction (ER) has been widely studied as a novel intervention, and its ability to prolong life has been fully demonstrated. For example, ER can significantly extend the lifespans of model flies, worms, rodents and other mammals. The role of ER in renal protection has also been elucidated. In preclinical studies, adjusting total energy intake or consumption of specific nutrients has prophylactic or therapeutic effects on ageing-related kidney disease and acute and chronic kidney injury. Amino acid restriction has gradually attracted attention. ER mimetics have also been studied in depth. The protective mechanisms of ER and ER mimetics for renal injury include increasing AMP-activated protein kinase and sirtuin type 1 (Sirt1) levels and autophagy and reducing mammalian target of rapamycin, inflammation and oxidative stress. However, the renal protective effect of ER has mostly been investigated in rodent models, and the role of ER in patients cannot be determined due to the lack of large randomised controlled trials. To protect the kidney, the mechanism of ER must be thoroughly researched, and more accurate diet or drug interventions need to be identified.

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References

Shimazu T, Hirschey M, Newman J, He W, Shirakawa K, Le Moan N . Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2012; 339(6116):211-4. PMC: 3735349. DOI: 10.1126/science.1227166. View

Kitada M, Kume S, Takeda-Watanabe A, Kanasaki K, Koya D . Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. Clin Sci (Lond). 2012; 124(3):153-64. PMC: 3466784. DOI: 10.1042/CS20120190. View

Gomez J, Caro P, Sanchez I, Naudi A, Jove M, Portero-Otin M . Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart. J Bioenerg Biomembr. 2009; 41(3):309-21. DOI: 10.1007/s10863-009-9229-3. View

Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N . Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism. Diabetes. 2011; 60(3):981-92. PMC: 3046859. DOI: 10.2337/db10-0655. View

Dong D, Cai G, Ning Y, Wang J, Lv Y, Hong Q . Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling. Oncotarget. 2017; 8(10):16109-16121. PMC: 5369951. DOI: 10.18632/oncotarget.14884. View

Sanchez-Roman I, Barja G . Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction. Exp Gerontol. 2013; 48(10):1030-42. DOI: 10.1016/j.exger.2013.02.021. View

Li J, Qu X, Ricardo S, Bertram J, Nikolic-Paterson D . Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3. Am J Pathol. 2010; 177(3):1065-71. PMC: 2928940. DOI: 10.2353/ajpath.2010.090923. View

Colman R, Anderson R, Johnson S, Kastman E, Kosmatka K, Beasley T . Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009; 325(5937):201-4. PMC: 2812811. DOI: 10.1126/science.1173635. View

Crowley M, Diamantidis C, McDuffie J, Cameron C, Stanifer J, Mock C . Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. Ann Intern Med. 2017; 166(3):191-200. PMC: 5293600. DOI: 10.7326/M16-1901. View

10.

Wang W, Cai G, Ning Y, Cui J, Hong Q, Bai X . Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats. Sci Rep. 2016; 6:30292. PMC: 4960595. DOI: 10.1038/srep30292. View

11.

Selamet U, Tighiouart H, Sarnak M, Beck G, Levey A, Block G . Relationship of dietary phosphate intake with risk of end-stage renal disease and mortality in chronic kidney disease stages 3-5: The Modification of Diet in Renal Disease Study. Kidney Int. 2015; 89(1):176-84. PMC: 4814358. DOI: 10.1038/ki.2015.284. View

12.

Fontana L, Cummings N, Arriola Apelo S, Neuman J, Kasza I, Schmidt B . Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Rep. 2016; 16(2):520-530. PMC: 4947548. DOI: 10.1016/j.celrep.2016.05.092. View

13.

Stenvinkel P, Kooman J, Shiels P . Nutrients and ageing: what can we learn about ageing interactions from animal biology?. Curr Opin Clin Nutr Metab Care. 2015; 19(1):19-25. DOI: 10.1097/MCO.0000000000000234. View

14.

Finch J, Lee D, Liapis H, Ritter C, Zhang S, Suarez E . Phosphate restriction significantly reduces mortality in uremic rats with established vascular calcification. Kidney Int. 2013; 84(6):1145-53. PMC: 6589836. DOI: 10.1038/ki.2013.213. View

15.

Friedman A, Chambers M, Kamendulis L, Temmerman J . Short-term changes after a weight reduction intervention in advanced diabetic nephropathy. Clin J Am Soc Nephrol. 2013; 8(11):1892-8. PMC: 3817909. DOI: 10.2215/CJN.04010413. View

16.

KEMPNER W . Some effects of the rice diet treatment of kidney disease and hypertension. Bull N Y Acad Med. 2010; 22:358-70. View

17.

Shavlakadze T, Zhu J, Wang S, Zhou W, Morin B, Egerman M . Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology. J Gerontol A Biol Sci Med Sci. 2018; 73(7):845-852. PMC: 6001891. DOI: 10.1093/gerona/glx249. View

18.

Rigalleau V, Blanchetier V, Combe C, Guillot C, Deleris G, AUBERTIN J . A low-protein diet improves insulin sensitivity of endogenous glucose production in predialytic uremic patients. Am J Clin Nutr. 1997; 65(5):1512-6. DOI: 10.1093/ajcn/65.5.1512. View

19.

Shang Z, Lu C, Chen S, Hua L, Qian R . Effect of H₂S on the circadian rhythm of mouse hepatocytes. Lipids Health Dis. 2012; 11:23. PMC: 3292508. DOI: 10.1186/1476-511X-11-23. View

20.

Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D . Protein-restricted diets plus keto/amino acids--a valid therapeutic approach for chronic kidney disease patients. J Ren Nutr. 2012; 22(2 Suppl):S1-21. DOI: 10.1053/j.jrn.2011.09.005. View