Pelargonidin-3-O-rutinoside As a Novel α-glucosidase Inhibitor for Improving Postprandial Hyperglycemia

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Nov 6

PMID 30394469

Citations 20

Authors

Yang Xu

Lianghua Xie

Jiahong Xie

Yu Liu

Wei Chen

Affiliations

Soon will be listed here.

Abstract

A novel strategy for the isolation of anthocyanins was developed by a combination of high-speed countercurrent chromatography (HSCCC) and HPLC techniques. Using this strategy, a novel α-glucosidase inhibitor (pelargonidin-3-O-rutinoside, a natural anthocyanin) was isolated from strawberries. Structural determinants for inhibition of α-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis.

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