CRISPRminer is a Knowledge Base for Exploring CRISPR-Cas Systems in Microbe and Phage Interactions

Overview

Journal Commun Biol

Specialty Biology

Date 2018 Nov 6

PMID 30393777

Citations 36

Authors

Fan Zhang

Shijia Zhao

Chunyan Ren

Yuwei Zhu

Haibin Zhou

Yongkui Lai

Fengxia Zhou

Yuqiang Jia

Kangjie Zheng

Zhiwei Huang

Affiliations

Soon will be listed here.

Abstract

CRISPR-Cas systems not only play key roles in prokaryotic acquired immunity, but can also be adapted as powerful genome editing tools. Understanding the native role of CRISPR-Cas systems in providing adaptive immunity can lead to new CRISPR-based technologies. Here, we develop CRISPRminer, a knowledge base and web server to comprehensively collect and investigate the knowledge of CRISPR-Cas systems and generate instructive annotations, including CRISPR arrays and Cas protein annotation, CRISPR-Cas system classification, self-targeting events detection, microbe-phage interaction inference, and anti-CRISPR annotation. CRISPRminer is user-friendly and freely available at http://www.microbiome-bigdata.com/CRISPRminer.

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